Description

(5α,12S,19α)-2,3-Didehydro-8α-[(18E)-18,19-Didehydroalstphyllan-18-Yl]-6β,7β-Epoxy-15-Hydroxy-16,17-Dimethoxyaspidospermidine-3-Carboxylic Acid Methyl Ester is a complex, high-purity indole alkaloid derivative of significant interest in advanced organic synthesis and pharmaceutical research. This compound serves as a critical advanced intermediate or reference standard for the development of novel bioactive molecules. It is primarily sought by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers engaged in exploring new therapeutic agents and complex natural product analogs.

Application

• Pharmaceutical Research & Development: As a key synthetic intermediate or building block for novel drug candidates targeting neurological disorders, cancer, or other therapeutic areas.
• Reference Standard in Analytical Chemistry: For use in HPLC, LC-MS, or NMR as a high-purity standard to identify, quantify, or characterize related alkaloids in complex mixtures.
• Medicinal Chemistry Studies: For structure-activity relationship (SAR) studies to understand the biological impact of specific functional groups on the aspidospermidine core.
• Natural Product Synthesis: As a sophisticated precursor in the total or semi-synthesis of complex indole alkaloids and their derivatives.
• Biochemical Research: For investigating interactions with biological targets such as enzymes or receptors, given its complex and potentially bioactive structure.
• Process Chemistry Development: For scaling up synthetic routes in fine chemical and active pharmaceutical ingredient (API) manufacturing.

Basic Information

Product Name	(5α,12S,19α)-2,3-Didehydro-8α-[(18E)-18,19-Didehydroalstphyllan-18-Yl]-6β,7β-Epoxy-15-Hydroxy-16,17-Dimethoxyaspidospermidine-3-Carboxylic Acid Methyl Ester
CAS No.	76282-39-8
Molecular Formula	C43H48N2O7
Molecular Weight	704.86 g/mol
Synonyms	Methyl (5α,12S,19α)-2,3-didehydro-8α-[(18E)-18,19-didehydroalstphyllan-18-yl]-6β,7β-epoxy-15-hydroxy-16,17-dimethoxyaspidospermidine-3-carboxylate; Alstiphyllanine E methyl ester; Alstiphyllanine E derivative; Aspidospermidine alkaloid derivative; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our production of this high-value alkaloid derivative adheres to strict quality management protocols. Each batch is characterized using advanced analytical techniques including NMR, HPLC, and MS to ensure structural integrity and purity. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We support cGMP standards for materials intended for pharmaceutical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. This compound is light-sensitive (store away from light) and should be handled under inert atmosphere when appropriate to prevent degradation. Keep the container in a dry, well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.