Description

Tetranor-Thromboxane B2 is a stable, major urinary metabolite of thromboxane A2, a potent prostanoid involved in platelet aggregation and vasoconstriction. This compound serves as a critical analytical standard and reference material for accurately quantifying in vivo thromboxane biosynthesis, which is a key biomarker for cardiovascular and inflammatory conditions. It is essential for researchers and quality control laboratories in the pharmaceutical, clinical diagnostics, and life science sectors who require high-purity standards for method development, validation, and biomarker analysis.

Application

• Biomarker Research: Used as a primary reference standard for the quantitative analysis of thromboxane metabolite levels in biological fluids (e.g., urine, plasma) to assess platelet activation and cardiovascular risk.
• Pharmaceutical Development: Employed in the research and development of anti-thrombotic and anti-inflammatory drugs, serving as a key analyte in pharmacokinetic and pharmacodynamic studies.
• Clinical Diagnostics: Critical for calibrating immunoassays (e.g., ELISA) and chromatographic methods (LC-MS/MS) used in clinical laboratories to monitor diseases related to eicosanoid imbalance.
• Life Science Research: Facilitates studies in biochemistry and physiology focused on arachidonic acid metabolism, cyclooxygenase pathways, and the role of prostanoids in cellular signaling.
• Quality Control & Method Validation: Acts as a certified reference material (CRM) to ensure the accuracy, precision, and reliability of analytical methods in contract research organizations (CROs) and regulatory testing.

Basic Information

Product Name	Tetranor-Thromboxane B2
CAS No.	76123-48-3
Molecular Formula	C₁₆H₂₈O₆
Molecular Weight	316.39 g/mol
Synonyms	2,3-Dinor-Thromboxane B2; 11-Dehydro-TXB2 metabolite; Tetranor-TXB2; Dinor-Thromboxane B2; 11-Dehydro-thromboxane B2 metabolite; TXB2 metabolite; Thromboxane B2 metabolite IV; 2,3-Dinor-11-dehydro-thromboxane B2
EINECS	Contact for details

Quality Control

Our Tetranor-Thromboxane B2 is produced under strict quality management systems to ensure the highest standards of purity and consistency, suitable for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles as determined by advanced chromatographic and spectroscopic methods. We adhere to relevant guidelines for reference standards, supporting compliance in GLP and ISO 17025-accredited environments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.