Description

(E)-4-Acetoxy Tamoxifen is a key pharmaceutical intermediate and a derivative of the well-known selective estrogen receptor modulator (SERM), Tamoxifen. This compound is primarily valued for its role in the synthesis and research of advanced anti-estrogen compounds, offering a crucial building block for medicinal chemistry. It is essential for pharmaceutical R&D laboratories, academic research institutions, and manufacturers focused on developing and producing oncology therapeutics, particularly for breast cancer research.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of Tamoxifen and its more potent active metabolites.
• Medicinal Chemistry Research: Used as a standard or reference compound in structure-activity relationship (SAR) studies for SERM development.
• Biochemical Research: Employed in studies investigating estrogen receptor binding mechanisms and antagonism.
• Academic & Institutional R&D: Serves as a key material in university and research institute laboratories for cancer-related pharmacological studies.
• Process Development: Utilized in scaling up and optimizing synthetic routes for anti-estrogen drug manufacturing.
• Analytical Standard: Acts as a high-purity standard for quality control and analytical method development (e.g., HPLC, LC-MS) in pharmaceutical analysis.

Basic Information

Product Name	(E)-4-Acetoxy Tamoxifen
CAS No.	76117-70-9
Molecular Formula	C26H29NO3
Molecular Weight	403.52 g/mol
Synonyms	4-Acetoxytamoxifen; (E)-4-[1-[4-(2-Dimethylaminoethoxy)phenyl]-2-phenyl-1-butenyl]phenyl acetate; (Z)-4-Acetoxytamoxifen (Isomer); Tamoxifen 4-acetate; NSC 108671; trans-4-Acetoxytamoxifen; 1-(4-β-Dimethylaminoethoxyphenyl)-1,2-diphenylbut-1-en-4-yl acetate
EINECS	Contact for details

Quality Control

Our (E)-4-Acetoxy Tamoxifen is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.