Description

2-Cyanoethyl Phosphorodichloridite is a highly reactive organophosphorus reagent primarily used as a key intermediate in the synthesis of complex molecules. Its core value lies in its ability to act as a versatile phosphitylating agent, enabling the efficient construction of phosphite and phosphate linkages under controlled conditions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and oligonucleotide synthesis industries, where it is used to create active ingredients and nucleotide analogs.

Application

• Phosphoramidite Synthesis: A critical precursor in the production of phosphoramidite monomers for automated solid-phase oligonucleotide (DNA/RNA) synthesis.
• Pharmaceutical Intermediates: Used in the synthesis of nucleotide-based prodrugs and other active pharmaceutical ingredients (APIs) with phosphate ester functionalities.
• Agrochemical Production: Serves as a building block for creating novel organophosphate and organophosphite pesticides and herbicides.
• Ligand and Catalyst Preparation: Employed in the preparation of specialized phosphite ligands for asymmetric catalysis and transition metal complexes.
• Chemical Research & Development: A valuable reagent for exploring new synthetic pathways in medicinal chemistry and material science.
• Flame Retardant Synthons: Can be utilized in the development of phosphorus-containing flame retardant additives for polymers.

Basic Information

Product Name	2-Cyanoethyl Phosphorodichloridite
CAS No.	76101-30-9
Molecular Formula	C3H4Cl2NOP
Molecular Weight	171.95 g/mol
Synonyms	2-Cyanoethyl Phosphorodichloridite; Phosphorodichloridous Acid 2-Cyanoethyl Ester; 2-Cyanoethyl Dichlorophosphite; (2-Cyanoethoxy)dichlorophosphine; 2-Cyanoethyl Dichlorophosphinite; CE Phosphorodichloridite
EINECS	Contact for details

Quality Control

Our 2-Cyanoethyl Phosphorodichloridite is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. Each lot is analyzed using advanced techniques including NMR, GC, and titration to confirm identity and assay. A comprehensive Certificate of Analysis (COA) detailing purity, moisture content, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C. This material is hygroscopic (moisture-sensitive) and easily oxidized; containers must be kept sealed and handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Purity (NMR)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.