Description

n-Succinimidyloxycarbonylpentyl Methanethiosulfonate is a heterobifunctional crosslinking reagent featuring an amine-reactive NHS ester and a thiol-reactive methanethiosulfonate (MTS) group. This compound is critical for creating stable, site-specific bioconjugates, enabling the controlled attachment of proteins, peptides, or other biomolecules. It is primarily utilized by researchers and manufacturers in the fields of bioconjugation, proteomics, antibody-drug conjugate (ADC) development, and diagnostic assay formulation.

Application

• Bioconjugation and Protein Labeling: For the site-specific modification of cysteine residues in proteins and antibodies with fluorescent dyes, drugs, or other functional molecules.
• Antibody-Drug Conjugate (ADC) Linker Chemistry: Serves as a key intermediate in the synthesis of cleavable or non-cleavable linkers for targeted cancer therapies.
• Surface Immobilization: Functionalizing gold surfaces, nanoparticles, or biosensor chips with biomolecules via the thiol-reactive group.
• Crosslinking Studies: Investigating protein-protein interactions or stabilizing protein complexes through the introduction of disulfide bonds.
• Diagnostic Reagent Synthesis: Creating enzyme conjugates or labeled antigens/antibodies for immunoassays (ELISA, lateral flow tests).
• Polymer Modification: Introducing thiol-reactive sites into polymers or hydrogels for subsequent biomolecule attachment.

Basic Information

Product Name	n-Succinimidyloxycarbonylpentyl Methanethiosulfonate
CAS No.	76078-81-4
Molecular Formula	C11H17NO6S2
Molecular Weight	323.39 g/mol
Synonyms	NHS-PEG5-MTS; 5-((2,5-Dioxopyrrolidin-1-yl)oxy)-5-oxopentyl methanesulfonothioate; Succinimidyl 5-(methanesulfonylthio)pentanoate; Methanethiosulfonate-PEG5-NHS ester; MTS-PEG5-NHS; 1-((Methanesulfonyl)thio)-6-((2,5-dioxopyrrolidin-1-yl)oxy)-6-oxohexane; S-Methanesulfonyl 6-((2,5-dioxopyrrolidin-1-yl)oxy)-6-oxohexanethioate
EINECS	Contact for details

Quality Control

Our n-Succinimidyloxycarbonylpentyl Methanethiosulfonate is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for sensitive research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) providing purity, identity, and impurity profiles is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This material is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.