Description

4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol is a nitrosamine derivative of significant interest in analytical and toxicological research. This compound is a key biomarker for assessing exposure to tobacco-specific nitrosamines, providing critical data for public health and regulatory studies. It is primarily utilized by research institutions, analytical laboratories, and pharmaceutical companies engaged in carcinogenicity studies, metabolic pathway analysis, and the development of sensitive detection methods. Our supply ensures high purity and batch-to-batch consistency, which is essential for generating reliable and reproducible scientific data.

Application

• Biomarker Reference Standard: Serves as a certified reference material (CRM) for the quantification of NNAL, a major metabolite of the tobacco-specific nitrosamine NNK, in biological matrices like urine and serum.
• Toxicological Research: Used in studies investigating the metabolism, DNA adduct formation, and carcinogenic mechanisms of tobacco-derived nitrosamines.
• Analytical Method Development: Essential for developing, validating, and calibrating highly sensitive analytical techniques such as LC-MS/MS, GC-MS, and ELISA for nitrosamine detection.
• Exposure Assessment: Employed in public health research to accurately measure human exposure to tobacco smoke and other sources of nitrosamines.
• Pharmaceutical Impurity Testing: Acts as a critical standard in monitoring and controlling genotoxic nitrosamine impurities (GTIs) in active pharmaceutical ingredients (APIs) and drug products, aligning with ICH M7 and regulatory guidelines.
• Forensic Analysis: Applied in forensic toxicology to provide definitive evidence of tobacco use or specific nitrosamine exposure.

Basic Information

Product Name	4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol
CAS No.	76014-81-8
Molecular Formula	C10H15N3O2
Molecular Weight	209.25 g/mol
Synonyms	NNAL; 4-(Methylnitrosamino)-1-(3-pyridinyl)-1-butanol; (RS)-NNAL; N'-Nitrosonornicotine metabolite; 1-(3-Pyridyl)-1-butanol-4-(methylnitrosamine); Tobacco-specific nitrosamine metabolite; 4-(N-Methyl-N-nitrosamino)-1-(3-pyridinyl)-1-butanone reduced alcohol
EINECS	Contact for details

Quality Control

Every batch of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol is produced and analyzed under strict quality management systems. We provide comprehensive analytical data to support its use as a high-purity reference standard. Our quality assurance includes identity confirmation by multiple spectroscopic methods, rigorous purity assessment by HPLC, and precise quantification. A detailed Certificate of Analysis (COA) containing batch-specific results for identity, purity, assay, and related substances is supplied with each shipment to ensure traceability and compliance with your research or quality control protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Keep the container sealed to prevent moisture absorption and contamination. For long-term storage, consider storing under inert atmosphere at lower temperatures (-20°C) to maximize stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Assay	97.0% - 103.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.