Description

(2,2'-L-Serine)-Gramicidin S is a synthetic, cyclic peptide derivative of the classic antibiotic Gramicidin S, engineered to incorporate L-serine residues at specific positions. This modification is designed to enhance its biological profile, potentially improving solubility, stability, or target specificity for advanced research applications. It serves as a critical tool for researchers in pharmaceutical development, antimicrobial studies, and peptide chemistry, where precise molecular structure is paramount for investigating structure-activity relationships.

Application

• Antimicrobial Research: As a structural analog of Gramicidin S, it is used in biochemical and microbiological studies to investigate novel mechanisms of action against bacteria, fungi, and other pathogens.
• Pharmaceutical Development: Serves as a key intermediate or reference standard in the R&D of new peptide-based antibiotics and therapeutic agents.
• Biochemical Tool: Utilized in membrane biophysics studies to examine the interactions of peptides with lipid bilayers and cellular membranes.
• Structure-Activity Relationship (SAR) Studies: The specific serine substitution makes it valuable for academic and industrial research aimed at understanding how amino acid modifications affect peptide potency, selectivity, and pharmacokinetics.
• Reference Standard: Employed as a high-purity calibrant in analytical methods such as HPLC and mass spectrometry for quality control in peptide synthesis.

Basic Information

Product Name	(2,2'-L-Serine)-Gramicidin S
CAS No.	75993-96-3
Molecular Formula	C60H92N12O12
Molecular Weight	1149.4 g/mol
Synonyms	Gramicidin S, (2,2'-L-Ser)-; Cyclo(-Val-Orn-Leu-D-Phe-Pro-)2, (2,2'-L-Ser) derivative; L-Serine modified Gramicidin S; GS Serine analog; Antimicrobial peptide derivative; [Ser2, Ser2']-Gramicidin S; Cyclic decapeptide antibiotic analog
EINECS	Contact for details

Quality Control

Our (2,2'-L-Serine)-Gramicidin S is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for demanding research applications. Quality is verified through a comprehensive suite of analytical techniques including HPLC, mass spectrometry, and NMR. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each batch to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain integrity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.