Description

Leukotriene E4 CAS NO 75715-89-8 is a potent cysteinyl leukotriene (CysLT) metabolite of arachidonic acid, playing a critical role in inflammatory and allergic responses. Its significance lies in its function as a key biomarker and research tool for studying asthma, allergic rhinitis, and other inflammatory diseases. This high-purity reference standard is essential for researchers and quality control laboratories in the pharmaceutical, biotechnology, and diagnostic sectors.

Application

• Biomarker Research: Quantitative analysis in biological samples for clinical studies on asthma, chronic obstructive pulmonary disease (COPD), and other respiratory conditions.
• Drug Discovery & Development: Critical reference standard for screening and validating potential leukotriene receptor antagonists and synthesis inhibitors.
• Diagnostic Kit Calibration: Used as a calibrator and control in ELISA and other immunoassay kits for measuring leukotriene levels.
• Metabolic Pathway Studies: Investigation of the 5-lipoxygenase pathway and eicosanoid signaling in inflammatory processes.
• Academic & Preclinical Research: Fundamental tool for in vitro and in vivo studies to elucidate the mechanisms of inflammation and allergy.
• Quality Control (QC): Serves as a system suitability standard in analytical methods (e.g., LC-MS/MS, HPLC) within pharmaceutical QC labs.

Basic Information

Product Name	Leukotriene E4
CAS No.	75715-89-8
Molecular Formula	C₂₃H₃₇NO₇S
Molecular Weight	471.60 g/mol
Synonyms	LTE4; Leukotriene E4; 5(S),6(R)-Dihydroxy-7,9,11,14-eicosatetraenoic acid, 5-(cysteinylglycinyl); (5S,6R)-5,6-Dihydroxyicosa-7,9,11,14-tetraenoylglycinate; 5(S),6(R)-LTE4; 5,6-DiHETE; N-[2-[[(4Z,7Z,9E,11E,14Z)-5,6-Dihydroxyicosa-4,7,9,11,14-pentaenoyl]amino]acetyl]glycine
EINECS	Contact for details

Quality Control

Our Leukotriene E4 is produced under stringent conditions to ensure the highest standards of purity and consistency, suitable for sensitive analytical and research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We adhere to rigorous internal quality standards to guarantee batch-to-batch reproducibility and reliability for your critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and easily oxidized; therefore, containers should be sealed under vacuum or nitrogen after each use and allowed to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in ethanol, methanol; slightly soluble in aqueous buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.