Description

12-Hydroxy Taurolithocholic Acid o-3-Glucuronide Dipotassium Salt is a high-purity, conjugated bile acid derivative, specifically a glucuronidated and taurine-conjugated form of lithocholic acid. This compound is of significant value as a critical reference standard and research reagent in the study of bile acid metabolism, detoxification pathways, and liver function. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and diagnostic manufacturers focused on hepatology, metabolomics, and the development of biomarkers for cholestatic liver diseases.

Application

• Pharmaceutical Reference Standard: Used for the qualitative and quantitative analysis of bile acid metabolites in method development, validation, and quality control for drug discovery and development.
• Biochemical Research: Serves as a crucial substrate or inhibitor in enzymatic studies related to glucuronidation (UGT enzymes) and bile acid conjugation pathways.
• Diagnostic Assay Development: Employed as a calibrator or control in the development of advanced clinical diagnostic kits for measuring specific bile acid profiles in serum or urine.
• Metabolomics & Biomarker Discovery: A key analyte in LC-MS/MS and HPLC-based metabolomic studies aiming to understand liver disease mechanisms and identify novel biomarkers.
• Toxicology Studies: Used to investigate the hepatotoxicity and detoxification mechanisms of various endogenous and exogenous compounds.

Basic Information

Product Name	12-Hydroxy Taurolithocholic Acid o-3-Glucuronide Dipotassium Salt
CAS No.	75672-37-6
Molecular Formula	C₃₆H₅₇K₂NO₁₅S
Molecular Weight	868.11 g/mol
Synonyms	12α-Hydroxytaurolithocholic acid 3-O-β-D-glucuronide dipotassium salt; Taurolithocholic acid 3-glucuronide dipotassium salt; 12-Hydroxy-3α-[(3α,5β,12α)-3,12-dihydroxy-24-oxocholan-24-yl]amino]-1,2,3,4,5-pentahydroxycyclohexane-1-carboxylic acid dipotassium salt; TLCA-3G dipotassium; 12-Hydroxy TLCA-3-Glucuronide K⁺ salt
EINECS	Contact for details

Quality Control

Our 12-Hydroxy Taurolithocholic Acid o-3-Glucuronide Dipotassium Salt is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and moisture uptake. For short-term use, store desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.