Description

Taurolithocholic Acid 3-o-Glucuronide Sulfate Disodium Salt is a highly specific, conjugated bile acid derivative of significant interest in biochemical and pharmaceutical research. This compound serves as a critical reference standard and intermediate for studying bile acid metabolism, transport, and signaling pathways. It is primarily utilized by research institutions, diagnostic kit manufacturers, and pharmaceutical companies engaged in hepatobiliary and metabolic disease research.

Application

• Biochemical Research Standard: Used as a high-purity reference material for the quantification and identification of bile acid metabolites in biological samples via LC-MS/MS or HPLC.
• Diagnostic Development: Serves as a key calibrator or control in the development of in-vitro diagnostic (IVD) assays for liver function and cholestatic diseases.
• Metabolic Pathway Studies: Essential for investigating the complex pathways of bile acid conjugation, sulfation, and glucuronidation in hepatocytes.
• Pharmaceutical Intermediates: Acts as a sophisticated building block or impurity standard in the synthesis and quality control of novel therapeutic agents targeting nuclear receptors like FXR and TGR5.
• Cell Culture & Toxicology: Employed in in-vitro studies to assess the effects of specific bile acid species on cell viability, inflammation, and transporter function.

Basic Information

Product Name	Taurolithocholic Acid 3-o-Glucuronide Sulfate Disodium Salt
CAS No.	75672-16-1
Molecular Formula	C36H55NNa2O17S2
Molecular Weight	899.92 g/mol
Synonyms	Tauro-3α-sulfolithocholylglycuronide Disodium Salt; Taurolithocholic Acid 3-Sulfate 3-Glucuronide Disodium Salt; TLCA-3S-3G Disodium; 3α-Sulfotaurolithocholylglycuronide Disodium; Sodium Taurolithocholate 3-Sulfate Glucuronide; (3α,5β)-3-[[(3α,5β,7α,12α)-3,7,12-Trihydroxy-24-oxocholan-24-yl]amino]-1-sulfo-1,2,3,4-tetrahydro-6H-pyrano[3,2-c]pyridine-6-carboxylic Acid Disodium Salt (conjugated form); Bile Acid Metabolite Standard
EINECS	Contact for details

Quality Control

Our Taurolithocholic Acid 3-o-Glucuronide Sulfate Disodium Salt is manufactured under a quality-focused system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via MS and NMR, to ensure it meets the stringent requirements for research and diagnostic use. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical methods is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines
Biological Activity	For research use only

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.