Description

S-(2-Chloroethyl)Glutathione is a specialized, synthetically modified derivative of the essential tripeptide glutathione. This compound is of significant interest in biochemical and pharmaceutical research due to its role as a model substrate and intermediate for studying glutathione S-transferase (GST) enzymes and alkylating agent metabolism. It serves as a critical tool for researchers and developers in pharmaceutical R&D, toxicology studies, and the synthesis of advanced biochemical probes. Its unique structure makes it valuable for investigating detoxification pathways and designing novel therapeutic agents.

Application

• Biochemical Research: Used as a specific substrate for studying the activity and kinetics of Glutathione S-transferase (GST) enzymes.
• Toxicology & Metabolism Studies: Serves as a model compound to investigate the metabolic fate and detoxification pathways of chloroethylating agents.
• Pharmaceutical Intermediate: Acts as a key synthetic building block in the development of prodrugs and targeted therapeutic molecules.
• Reference Standard: Employed as a high-purity analytical standard in HPLC, LC-MS, and NMR for method development and validation in quality control laboratories.
• Mechanistic Probe: Utilized to elucidate reaction mechanisms involving nucleophilic attack by the glutathione thiol group on electrophilic centers.

Basic Information

Product Name	S-(2-Chloroethyl)Glutathione
CAS No.	75607-61-3
Molecular Formula	C12H21ClN3O6S
Molecular Weight	370.83 g/mol
Synonyms	S-(2-Chloroethyl)glutathione; γ-Glutamyl-S-(2-chloroethyl)cysteinylglycine; Glutathione S-(2-chloroethyl) ester; NSC 401005; L-γ-Glutamyl-S-(2-chloroethyl)-L-cysteinylglycine; S-(2-Chloroethyl)-L-glutathione; Chloroethylglutathione
EINECS	Contact for details

Quality Control

Every batch of S-(2-Chloroethyl)Glutathione is manufactured and analyzed under strict quality management protocols. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure high purity and batch-to-batch consistency suitable for research applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.