Description

P1,P5-Di(Adenosine-5'-)Pentaphosphate, Trilithium Salt is a high-purity, chemically defined dinucleotide analog used extensively in biochemical research and diagnostic applications. This compound serves as a potent and specific inhibitor of adenylate kinase, making it a critical tool for studying cellular energy metabolism and nucleotide-dependent signaling pathways. It is primarily utilized by researchers in pharmaceutical development, academic institutions, and diagnostic kit manufacturers requiring precise enzyme modulation.

Application

• Biochemical Research: As a specific inhibitor of adenylate kinase (AK) isoforms (AK1, AK2) in mechanistic and kinetic studies of ATP-AMP transphosphorylation.
• Diagnostic Assay Development: A key component in commercial and research-grade assay kits for measuring creatine kinase (CK), adenylate kinase, and other ATP-regulating enzymes, where it suppresses background AK activity.
• Cellular Metabolism Studies: Used to probe the role of adenylate kinase in maintaining adenine nucleotide homeostasis within cells, mitochondria, and other organelles.
• Pharmaceutical Screening: Employed in high-throughput screening (HTS) platforms to identify novel therapeutic compounds that target energy metabolism pathways in areas like cardiology, oncology, and metabolic disorders.
• Enzyme Purification: Utilized in affinity chromatography for the isolation and purification of adenylate kinase from complex biological mixtures.
• Standard Reference Material: Serves as a certified reference standard for quality control in diagnostic manufacturing and academic research to ensure assay consistency and accuracy.

Basic Information

Product Name	P1,P5-Di(Adenosine-5'-)Pentaphosphate, Trilithium Salt
CAS No.	75522-97-3
Molecular Formula	C20H22Li3N10O22P5
Molecular Weight	902.10 g/mol (anhydrous basis)
Synonyms	Ap5A, Lithium Salt; Diadenosine pentaphosphate, Trilithium salt; P1,P5-Di(adenosine-5')pentaphosphate; Adenosine pentaphosphate derivative; AK inhibitor; Adenylate kinase inhibitor; AP5A, Li+ salt; 5'-Adenylyl (P1→P5)-pentaphospho-(P5→1)-adenosine, trilithium salt
EINECS	Contact for details

Quality Control

Our P1,P5-Di(Adenosine-5'-)Pentaphosphate, Trilithium Salt is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for research and diagnostic use. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Conforms to reference standard
Identification (UV)	Conforms (λmax ~259 nm)
Assay (HPLC)	≥95% (Area Percent)
Water Content (KF)	≤5.0%
Solubility	Soluble in water, slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.