Description

Tetrahydro-2H-Pyran-2-Ylmethyl 4-Methylbenzenesulfonate is a high-purity chemical intermediate, also known as THP-protected tosylate, valued for its role as a versatile protecting group reagent in complex organic synthesis. Its primary commercial value lies in enabling selective reactions and improving yields in the production of pharmaceuticals and advanced materials. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for nucleoside and carbohydrate-based drugs.
• Protecting Group Chemistry: Used to protect hydroxyl groups during multi-step synthetic sequences, offering stability under a range of reaction conditions.
• Agrochemical Synthesis: Intermediate in the production of complex herbicides, fungicides, and plant growth regulators.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, flavors, fragrances, and liquid crystals.
• Academic & Industrial R&D: A critical reagent for method development and exploratory synthesis in research laboratories.
• Peptide Synthesis: Can be utilized in the protection of specific amino acid side chains during solid-phase peptide synthesis.

Basic Information

Product Name	Tetrahydro-2H-Pyran-2-Ylmethyl 4-Methylbenzenesulfonate
CAS No.	75434-63-8
Molecular Formula	C13H18O4S
Molecular Weight	270.34 g/mol
Synonyms	THP-O-tosylate; (Tetrahydro-2H-pyran-2-yl)methyl 4-methylbenzenesulfonate; 2-(Tosyloxymethyl)tetrahydropyran; Tetrahydropyran-2-ylmethyl p-toluenesulfonate; THP-OTs; Tosyloxymethyltetrahydropyran; 4-Methylbenzenesulfonic acid tetrahydro-2H-pyran-2-ylmethyl ester
EINECS	Contact for details

Quality Control

Our Tetrahydro-2H-Pyran-2-Ylmethyl 4-Methylbenzenesulfonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC analysis, to ensure high chemical purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for critical synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent decomposition. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.