Description

1,4,8-Trideoxy-1,4-Dihydro-3-Hydroxy-1,4-Dioxorifamycin CAS NO 75352-23-7 is a key semi-synthetic derivative of the rifamycin class, valued for its potent biological activity and role as a crucial intermediate in advanced pharmaceutical synthesis. This compound is engineered to provide a strategic building block for developing next-generation antimicrobial and anti-tuberculosis agents, offering researchers and manufacturers a high-purity starting point for complex chemical transformations. It is primarily sought by pharmaceutical R&D laboratories and fine chemical producers engaged in the development of novel antibiotic therapies and specialized active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of novel rifamycin-based antibiotics and other therapeutic agents.
• Antimicrobial Research: Serves as a core scaffold in medicinal chemistry programs aimed at discovering new compounds with activity against drug-resistant bacterial strains.
• Anti-Tuberculosis Drug Development: Used in R&D for creating improved analogs targeting Mycobacterium tuberculosis, addressing global health challenges.
• Biochemical Research: Employed in studies investigating the mechanism of action of RNA polymerase inhibitors and bacterial transcription.
• Fine Chemical Synthesis: Utilized as a specialized building block for constructing complex molecular architectures in custom synthesis projects.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control in API manufacturing.

Basic Information

Product Name	1,4,8-Trideoxy-1,4-Dihydro-3-Hydroxy-1,4-Dioxorifamycin
CAS No.	75352-23-7
Molecular Formula	C37H45NO12
Molecular Weight	695.75 g/mol
Synonyms	1,4,8-Trideoxy-1,4-dihydro-3-hydroxy-1,4-dioxorifamycin; 3-Hydroxy-1,4,8-trideoxy-1,4-dihydro-1,4-dioxorifamycin; Rifamycin Derivative 75352-23-7; 1,4-Dioxorifamycin S; 25-Deacetyl-1,4,8-trideoxy-1,4-dihydro-3-hydroxy-1,4-dioxorifamycin; Antibiotic CP 40,176; CP-40176
EINECS	Contact for details

Quality Control

Our 1,4,8-Trideoxy-1,4-Dihydro-3-Hydroxy-1,4-Dioxorifamycin is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality protocols are designed to meet the stringent requirements of pharmaceutical intermediate supply.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive (store away from light) and should be handled under an inert atmosphere for long-term storage to maintain stability. Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	Reddish-brown to orange powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.