Description

Fully Protected Deoxynucleotide Dimerd(T Ptp) CAS NO 75251-83-1 is a high-purity, chemically modified nucleoside building block essential for oligonucleotide synthesis. Its core value lies in providing precise control over DNA sequence assembly, ensuring high coupling efficiency and yield in automated solid-phase synthesis. This critical reagent is primarily needed by pharmaceutical R&D teams, diagnostic developers, and academic research institutions engaged in the production of antisense oligonucleotides, primers, probes, and other synthetic nucleic acids.

Application

• Solid-Phase Oligonucleotide Synthesis: As a key phosphoramidite monomer for the automated synthesis of DNA strands.
• Antisense Oligonucleotide (ASO) Development: For the research and manufacturing of therapeutic nucleic acids targeting specific genes.
• PCR Primer and Probe Synthesis: Enables the production of highly specific and sensitive primers and probes for molecular diagnostics and qPCR.
• Gene Synthesis and Cloning: A fundamental component in the assembly of long DNA fragments and synthetic genes.
• Next-Generation Sequencing (NGS) Library Preparation: Used in the synthesis of adapters and custom barcodes for sequencing workflows.
• Research-Grade Oligo Production: For academic and industrial labs requiring custom DNA sequences for functional studies.

Basic Information

Product Name	Fully Protected Deoxynucleotide Dimerd(T Ptp)
CAS No.	75251-83-1
Molecular Formula	C31H39N4O13P
Molecular Weight	706.64 g/mol
Synonyms	dT(PTP) Dimer; Thymidine 3'-(4,4'-Dimethoxytrityl)-5'-(2-Cyanoethyl N,N-Diisopropylphosphoramidite); 5'-O-(4,4'-Dimethoxytrityl)thymidine 3'-[2-cyanoethyl N,N-diisopropylphosphoramidite]; DMT-dT-CE Phosphoramidite; Fully Protected dT Phosphoramidite; dT-CE Phosphoramidite; DNA Synthesis Reagent dT; Thymidine Phosphoramidite Dimer
EINECS	Contact for details

Quality Control

Our Fully Protected Deoxynucleotide Dimerd(T Ptp) is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for sensitive synthesis applications. Each lot undergoes comprehensive analytical testing, including HPLC purity analysis, ³¹P NMR for structural confirmation, and moisture content (KF) determination. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (argon or nitrogen) in a desiccated environment. This product is hygroscopic and moisture-sensitive; allow the sealed vial to equilibrate to room temperature before opening to prevent condensation. For long-term stability, keep the material dry and avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (³¹P NMR)	Conforms to reference standard
Purity (HPLC)	≥ 98.5%
Moisture Content (KF)	≤ 0.5%
Solubility	Clear, colorless solution in anhydrous acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.