Description

(+)-Nicotine CAS NO 75202-10-7 is the naturally occurring, dextrorotatory enantiomer of nicotine, a potent alkaloid. This high-purity form is critical for research and development where stereochemical specificity is required, ensuring accurate pharmacological and toxicological data. It serves as an essential reference standard and active ingredient for the pharmaceutical, agrochemical, and life science industries.

Application

• Pharmaceutical Reference Standard: Used for the calibration of analytical instruments, method validation, and quality control in drug development and forensic analysis.
• Neuroscience & Behavioral Research: A key tool for studying nicotinic acetylcholine receptors (nAChRs), addiction mechanisms, and cognitive functions.
• Agrochemical Intermediate: Serves as a precursor or model compound in the synthesis of novel neonicotinoid insecticides and other crop protection agents.
• E-liquid & Nicotine Replacement Therapy (NRT) Formulation: Employed in the development and standardization of smoking cessation products like gums, patches, and inhalers.
• Biochemical Assay Development: Utilized in creating in-vitro and in-vivo assays to screen for new therapeutics targeting nicotine dependence.
• Metabolite & Impurity Synthesis: Acts as a starting material for the synthesis of nicotine metabolites (e.g., cotinine) for clinical and diagnostic research.

Basic Information

Product Name	(+)-Nicotine
CAS No.	75202-10-7
Molecular Formula	C10H14N2
Molecular Weight	162.23 g/mol
Synonyms	(S)-(-)-Nicotine; (S)-Nicotine; L-Nicotine; (-)-Nicotine; Levonikotin; 3-[(2S)-1-Methylpyrrolidin-2-yl]pyridine; (S)-3-(1-Methyl-2-pyrrolidinyl)pyridine; Nicotine S-(-)-form
EINECS	200-193-3

Quality Control

Our (+)-Nicotine is manufactured under strict quality systems. Each batch is analyzed to meet high-purity standards, typically exceeding 99% by HPLC, with stringent control over related substances and enantiomeric excess. Certificates of Analysis (COA) detailing identity, purity, and specific tests are provided with every shipment to ensure traceability and compliance with research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C. Due to its hygroscopic and highly volatile nature, the container must be kept tightly sealed in a cool, dry, and well-ventilated place. Keep away from heat and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (HPLC)	≥ 99.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.5%
Related Substances (HPLC)	Total impurities ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.