Description

L-Glucose-[1-3H(N)] is a radiolabeled stereoisomer of glucose, specifically tritiated at the C-1 position, with the CAS registry number 75013-51-3. This compound is a critical tool for metabolic research, enabling the precise tracing of L-glucose pathways and the study of stereospecific transport mechanisms in biological systems. It is essential for researchers and scientists in pharmaceutical development, biochemistry, and metabolic disease research who require high-specific-activity tracers for in vitro and in vivo studies.

Application

• Metabolic Pathway Tracing: Used as a non-metabolizable tracer to study glucose transport and uptake mechanisms in cells and tissues, particularly for investigating stereospecificity.
• Pharmacokinetic Studies: Employed in ADME (Absorption, Distribution, Metabolism, Excretion) research to track the fate of L-glucose analogs and related pharmaceutical compounds.
• Membrane Transport Research: Vital for characterizing and quantifying the activity of glucose transporters (GLUTs and SGLTs) and assessing blood-brain barrier permeability.
• Biochemical Assay Development: Serves as a standard or tracer in developing and validating assays for sugar metabolism and enzyme function.
• Medical Research: Applied in studies related to diabetes, cancer metabolism, and other disorders where altered glucose metabolism is a key factor.

Basic Information

Product Name	L-Glucose-[1-3H(N)]
CAS No.	75013-51-3
Molecular Formula	C6H113HO6
Molecular Weight	~183.2 g/mol (for unlabeled form)
Synonyms	(1-3H)-L-Glucose; L-Glucose (1-tritiated); 1-Tritio-L-glucose; L-3H-Glucose; L-Glucose-1-t; L-Glucose (tritium labeled); L-(-)-Glucose-[1-3H]; 75013-51-3
EINECS	Contact for details

Quality Control

Every batch of L-Glucose-[1-3H(N)] is manufactured and analyzed under strict quality systems. We provide comprehensive Certificates of Analysis (COA) detailing critical parameters such as radiochemical purity, specific activity, and chemical purity, typically determined by HPLC and scintillation counting. Our quality commitment ensures the material meets the stringent requirements for research and diagnostic applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in the original solvent (usually aqueous ethanol) as specified on the label. This product is light-sensitive and should be stored away from light. Due to its radiolabeled nature and volatility of possible degradation products, appropriate laboratory safety and radioactive material handling protocols must be followed.

Specification

Item	Specification
Appearance	Clear, colorless solution
Identification (HPLC)	Conforms
Radiochemical Purity	≥ 97%
Specific Activity	10-40 Ci/mmol (Contact for specific value)
Chemical Purity (HPLC)	≥ 95%
Solvent	Ethanol/Water (as specified on label)
Concentration	1 mCi/mL (Nominal)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.