Description

2-Hydroxyestradiol 17-Sulfate is a sulfated metabolite of the endogenous estrogen, 2-hydroxyestradiol, playing a significant role in hormone metabolism and signaling pathways. This compound is of high value for research and development in endocrinology and pharmacology, serving as a critical reference standard and biochemical tool. It is primarily utilized by pharmaceutical R&D teams, clinical research organizations, and academic institutions focused on steroid hormone analysis, metabolic studies, and the development of diagnostic assays.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified reference material (CRM) for the quantitative analysis of estrogen metabolites in drug development and bioanalytical studies.
• Biochemical Research: Serves as a key reagent in studying estrogen sulfation pathways, enzyme kinetics of sulfotransferases, and hormonal regulation mechanisms.
• Clinical Diagnostics: Employed in the calibration and development of LC-MS/MS and immunoassay kits for the precise measurement of sulfated estrogen levels in biological samples.
• Metabolite Profiling: Essential for creating metabolic profiles to understand estrogen metabolism in various disease states, including hormone-dependent cancers.
• Toxicology Studies: Used in investigations of endocrine-disrupting chemicals and their effects on steroid hormone synthesis and conjugation.

Basic Information

Product Name	2-Hydroxyestradiol 17-Sulfate
CAS No.	75005-50-4
Molecular Formula	C18H22O6S
Molecular Weight	366.43 g/mol
Synonyms	2-Hydroxyestradiol 17-Sulfate; Estra-1,3,5(10)-triene-2,3,17-triol 17-Sulfate; 2,3,17-Trihydroxyestra-1,3,5(10)-trien-17-yl Sulfate; 2-Hydroxyestradiol Sulfate; 2-OHE2-17-Sulfate; 2-Hydroxy-Estradiol-17-Sulfate; 2-Hydroxyestradiol 17-(Hydrogen Sulfate)
EINECS	Contact for details

Quality Control

Every batch of 2-Hydroxyestradiol 17-Sulfate is manufactured and analyzed under strict quality management protocols. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure identity, purity, and consistency that meet the stringent requirements for research-grade biochemicals. Certificates of Analysis (COA) with detailed chromatographic data are provided with each shipment to guarantee traceability and compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.