Description

4-Amidinophenylmethanesulfonyl Fluoride Hydrochloride is a high-purity, irreversible serine protease inhibitor, widely recognized for its role in biochemical research and pharmaceutical development. This compound is critical for studying enzyme mechanisms and developing targeted therapeutic agents. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies focused on protease-related pathways.

Application

• Biochemical Research: As a potent and irreversible inhibitor of trypsin-like serine proteases for mechanistic studies.
• Pharmaceutical Development: Serves as a key intermediate or active pharmacophore in the design of novel protease-targeting drugs.
• Diagnostic Reagent Formulation: Used in the preparation of enzyme assay kits and diagnostic reagents to control specific protease activity.
• Cell Biology & Proteomics: Employed to inhibit specific proteases in cell lysates and protein samples to prevent unwanted degradation during analysis.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Item	Details
Product Name	4-Amidinophenylmethanesulfonyl Fluoride Hydrochloride
CAS No.	74938-88-8
Molecular Formula	C8H10FN3O2S • HCl
Molecular Weight	267.70 g/mol (Free base: 231.25 g/mol)
Synonyms	APMSF • HCl; 4-Amidinophenylmethylsulfonyl Fluoride Hydrochloride; (4-Amidinophenyl)methanesulfonyl Fluoride Hydrochloride; p-Amidinophenylmethanesulfonyl Fluoride Hydrochloride; Protease Inhibitor APMSF; Amidinophenylmethanesulfonyl Fluoride HCl; EINECS Not Available

Quality Control

Our 4-Amidinophenylmethanesulfonyl Fluoride Hydrochloride is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and loss on drying. We provide Certificates of Analysis (COA) with detailed specifications for traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.