Description

1-Hexadecanoyl-2-[(Cis,Cis,Cis,Cis)-5,8,11,14-Eicosatetraenoyl]-Sn-Glycero-3-Phosphocholine is a defined, high-purity phospholipid essential for advanced biochemical and pharmaceutical research. This compound is a critical reagent for studying membrane biophysics, lipid signaling pathways, and the formulation of lipid-based drug delivery systems. It is primarily utilized by researchers and developers in the life sciences, pharmaceutical development, and advanced material science sectors.

Application

• Lipidomics & Biomembrane Research: As a standard or substrate for studying phospholipid metabolism, membrane fluidity, and lipid-protein interactions.
• Liposome & Nanoparticle Formulation: A key component in the development of liposomal drug carriers, mRNA-LNPs (lipid nanoparticles), and other nanomedicine platforms.
• Biochemical Assay Development: Used as a substrate for phospholipase enzymes (e.g., PLA2) in enzyme activity and inhibitor screening assays.
• Cell Culture & Signaling Studies: Incorporated into serum-free media or delivery systems to investigate the role of specific phospholipids in cellular processes.
• Pharmaceutical Reference Standard: Serves as a certified reference material for quality control and analytical method development in drug product characterization.
• Model Membrane Systems: Used to create defined lipid bilayers (e.g., supported lipid bilayers, vesicles) for biophysical studies and biosensor applications.

Basic Information

Item	Details
Product Name	1-Hexadecanoyl-2-[(Cis,Cis,Cis,Cis)-5,8,11,14-Eicosatetraenoyl]-Sn-Glycero-3-Phosphocholine
CAS No.	74936-60-0
Molecular Formula	C44H80NO8P
Molecular Weight	782.09 g/mol
Synonyms	16:0-20:4 PC; 1-Palmitoyl-2-Arachidonoyl-sn-Glycero-3-Phosphocholine; PAPC; 1-Palmitoyl-2-Arachidonoyl Phosphatidylcholine; PA-PC; Phosphatidylcholine (16:0/20:4(5Z,8Z,11Z,14Z)); 1-Palmitoyl-2-Arachidonoyl-GPC; 1-Hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine
EINECS	Contact for details

Quality Control

Our high-purity phospholipids are manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization using techniques including HPLC, NMR, and MS to confirm identity, purity, and lipid composition. Certificates of Analysis (COA) with detailed chromatographic data are provided to ensure traceability and batch-to-batch consistency for your critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen). This product is both hygroscopic (moisture-sensitive) and easily oxidized; allow the sealed vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake and oxidative degradation.

Specification

Item	Specification
Appearance	White to off-white waxy solid or film
Identification (HPLC/MS)	Complies
Purity (HPLC)	≥ 95% (Area %)
Solvent Content (Residual Solvent)	≤ 2.0% (by NMR or GC)
Water Content (Karl Fischer)	≤ 1.0%
Peroxide Value	≤ 5.0 mEq/kg
Lyso-Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.