Description

1-Hexadecyl-2-Tetradecyl-Glycero-3-Phosphocholine is a high-purity synthetic phospholipid, specifically an ether-linked phosphatidylcholine analog. This compound is valued for its unique structural stability and its critical role as a key component in the formulation of advanced lipid-based delivery systems. It is primarily required by R&D and manufacturing teams in the pharmaceutical, biotechnology, and advanced cosmetics industries for developing next-generation therapeutics and high-performance formulations.

Application

• Liposome and Lipid Nanoparticle (LNP) Formulation: A critical structural phospholipid for creating stable, non-labile membranes in drug delivery vehicles for mRNA, siRNA, and small molecule therapeutics.
• Biomimetic Membrane Research: Used to construct model cell membranes and vesicles (e.g., giant unilamellar vesicles) for studying membrane biophysics, protein-lipid interactions, and cellular processes.
• Drug Solubilization & Encapsulation: Enhances the solubility and bioavailability of poorly water-soluble active pharmaceutical ingredients (APIs) through micellar or liposomal encapsulation.
• Cosmetic Actives Delivery: Serves as a premium-grade ingredient in high-end cosmetic and dermatological formulations for the targeted and sustained delivery of vitamins, antioxidants, and other actives.
• Diagnostic Reagent Component: Incorporated into reagents and kits used for clinical diagnostics and biochemical assays that require specific membrane environments.
• Cell Culture & Transfection: Utilized in specialized cell culture media supplements and as a component in non-viral transfection reagents to improve efficiency.

Basic Information

Product Name	1-Hexadecyl-2-Tetradecyl-Glycero-3-Phosphocholine
CAS No.	74838-89-4
Molecular Formula	C₄₀H₈₂NO₆P
Molecular Weight	716.06 g/mol
Synonyms	1-O-Hexadecyl-2-O-tetradecyl-sn-glycero-3-phosphocholine; DCPC (Di-O-alkyl Phosphatidylcholine); 1,2-Di-O-alkyl-sn-glycero-3-phosphocholine (C16:0/C14:0); Ether PC(30:0); Phosphatidylcholine, 1-hexadecyl-2-tetradecyl-; 1-Hexadecyl-2-tetradecylphosphatidylcholine; 1,2-Dialkylphosphatidylcholine; 1,2-Di-O-alkylphosphatidylcholine
EINECS	Contact for details

Quality Control

Our 1-Hexadecyl-2-Tetradecyl-Glycero-3-Phosphocholine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical and research applications. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white waxy solid or film
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Solvent Residue (GC)	Meets ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.