Description

Spermine Synthase is a critical enzyme in the polyamine biosynthesis pathway, responsible for the final step in the production of spermine from spermidine. This compound is essential for researchers and manufacturers in the life sciences sector, enabling the study and modulation of cellular growth, proliferation, and apoptosis. It is primarily utilized by pharmaceutical R&D teams, diagnostic kit developers, and academic institutions focused on biochemistry, oncology, and neurobiology.

Application

• Biochemical Research: Used as a substrate or reference standard in enzymatic assays to study polyamine metabolism and its role in cellular processes.
• Pharmaceutical Development: Employed in drug discovery programs targeting diseases associated with dysregulated polyamine levels, such as certain cancers and neurological disorders.
• Diagnostic Manufacturing: Serves as a key component in the production of enzyme-linked immunosorbent assay (ELISA) kits and other in vitro diagnostic reagents.
• Enzyme Characterization: Essential for kinetic studies, inhibitor screening, and determining the specific activity of spermine synthase enzymes.
• Cell Culture & Physiology Studies: Applied in cell-based assays to investigate the effects of polyamine synthesis on growth, differentiation, and stress response.

Basic Information

Product Name	Spermine Synthase
CAS No.	74812-43-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Spermidine Aminopropyltransferase; Spermidine Synthase (ambiguous); Polyamine Synthase; EC 2.5.1.22; Aminopropyltransferase (spermine-specific); Spermine Synthase Enzyme
EINECS	Contact for details

Quality Control

Our Spermine Synthase is produced and tested under stringent quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity, specific activity, and consistency. Certificates of Analysis (COA) detailing purity (by HPLC), protein concentration, specific activity, and absence of contaminating proteases or nucleases are available upon request. Our quality commitment supports compliance with research and diagnostic manufacturing standards.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. This material is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	Lyophilized powder or solution
Purity (SDS-PAGE)	> 90%
Specific Activity	≥ [Value] units/mg protein
Protein Concentration	Determined by Bradford or UV absorbance
Buffer Composition	Tris-HCl, Glycerol, DTT (typical)
Endotoxin Level	< 1.0 EU/μg (if applicable)
Storage Buffer	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.