Description

3'''-Diazomalonyldigitoxin is a chemically modified derivative of the cardiac glycoside digitoxin, characterized by the introduction of a diazomalonyl group. This compound is of significant interest as a key synthetic intermediate and a versatile molecular scaffold in advanced pharmaceutical research and development. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of novel bioactive compounds, particularly for cardiovascular and oncology-related applications.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block for the synthesis of novel cardiac glycoside derivatives with potential therapeutic applications.
• Biochemical Research: Used in the study of sodium-potassium ATPase (Na+/K+-ATPase) inhibition and related cellular signaling pathways.
• Probe Development: Acts as a precursor for photoaffinity labeling probes to investigate drug-receptor interactions and protein binding sites.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to optimize the potency and selectivity of digitoxin analogs.
• Anticancer Research: Investigated for the development of derivatives targeting cancer cell proliferation and survival mechanisms.
• Academic Synthesis: Used in advanced organic chemistry laboratories for teaching and methodology development in heterocyclic and steroid chemistry.

Basic Information

Item	Detail
Product Name	3'''-Diazomalonyldigitoxin
CAS No.	74753-41-6
Molecular Formula	C₄₇H₆₆N₂O₁₄
Molecular Weight	883.04 g/mol
Synonyms	Digitoxin, 3'''-[(diazomalonyl)amino]-3'''-deoxy-; 3'''-Diazomalonylamino-3'''-deoxydigitoxin; 3'-Diazomalonyldigitoxin; 3'''-Diazomalonyl-digitoxin; Diazomalonyldigitoxin
EINECS	Contact for details

Quality Control

Our 3'''-Diazomalonyldigitoxin is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR). We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade material standards. Specifications can be aligned with client requirements for specific research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.