Description

C2 Sphingomyelin (D18:1/2:0) is a defined, synthetic sphingolipid with a short-chain C2 fatty acid (acetate) at the sn-2 position of the glycerol backbone. This specific molecular configuration makes it a critical reference standard and a valuable building block for lipidomics research and membrane biophysics studies. It is essential for researchers and manufacturers in the pharmaceutical and life science sectors who require high-purity, structurally-defined lipids for analytical calibration, drug delivery system development, and investigating lipid raft dynamics and cell signaling pathways.

Application

• Lipidomics Research & Analytical Standards: Serves as a high-purity quantitative and qualitative reference standard for mass spectrometry (LC-MS/MS) and other analytical techniques to identify and quantify sphingomyelins in complex biological samples.
• Membrane Biophysics Studies: Used to create model lipid bilayers and vesicles to study membrane fluidity, phase behavior, and the formation of lipid rafts due to its defined structure.
• Pharmaceutical Excipient & Drug Delivery: Investigated as a component in liposomal and nanoparticle formulations to enhance stability, modify release profiles, and target specific tissues.
• Cell Biology & Signaling Research: Employed in studies to understand the role of sphingomyelin and its metabolites in apoptosis, proliferation, and stress responses within cells.
• Biochemical Reagent Production: Acts as a substrate or precursor for enzymes like sphingomyelinase or for the synthesis of more complex, labeled sphingolipid derivatives.
• Cosmeceutical R&D: Explored in high-end skincare research for its potential role in skin barrier function and ceramide precursor activity.

Basic Information

Product Name	C2 Sphingomyelin (D18:1/2:0)
CAS No.	74713-54-5
Molecular Formula	C45H89N2O6P
Molecular Weight	785.18 g/mol
Synonyms	N-[(2S,3R,4E)-1,3-Dihydroxyoctadec-4-en-2-yl]-2-(trimethylammonio)ethyl hydrogen phosphate acetate; N-Acetyl-D-erythro-sphingosylphosphorylcholine; SM(d18:1/2:0); Sphingomyelin (d18:1, C2:0); 1-Oleoyl-2-acetyl-sn-glycero-3-phosphocholine (structural analog context); Lyso-Sphingomyelin C2; Synthetic Sphingomyelin Acetate; C2-SM
EINECS	Contact for details

Quality Control

Our C2 Sphingomyelin is manufactured under strict quality systems to ensure batch-to-batch consistency and high chemical purity, suitable for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity assessment and mass spectrometry for structural confirmation. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). For long-term storage, consider under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Assay (by NMR)	≥ 90% (w/w)
Water Content (KF)	≤ 5.0 %
Solubility	Soluble in chloroform, methanol, DMSO; slightly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.