Description

Dansyl-L-Citrulline is a fluorescently labeled derivative of the amino acid L-citrulline, designed for advanced biochemical research and analysis. This compound is critical for studying nitric oxide synthase (NOS) activity, protein citrullination, and post-translational modifications with high sensitivity. It is primarily utilized by research institutions, pharmaceutical R&D departments, and diagnostic kit manufacturers engaged in proteomics, enzyme kinetics, and biomarker discovery.

Application

• Biochemical Research Probe: Used as a fluorescent substrate or tracer in enzymatic assays, particularly for nitric oxide synthase (NOS) activity studies.
• Proteomics & PTM Analysis: Essential for the detection and quantification of protein citrullination (deimination) in studies of autoimmune diseases, epigenetics, and cell signaling.
• Pharmaceutical Development: Serves as a key intermediate or reference standard in the development of therapeutics targeting NOS pathways or citrullination-related disorders.
• Diagnostic Assay Development: Employed in the formulation of high-sensitivity ELISA or fluorescence-based diagnostic kits for detecting anti-citrullinated protein antibodies (ACPAs).
• Chromatographic Standards: Acts as a high-purity reference standard for HPLC, LC-MS, and other analytical method development and validation.

Basic Information

Product Name	Dansyl-L-Citrulline
CAS No.	74672-25-6
Molecular Formula	C17H24N4O5S
Molecular Weight	396.46 g/mol
Synonyms	5-(Dimethylamino)naphthalene-1-sulfonyl-L-citrulline; Dansyl-L-citrulline; N5-(5-Dimethylaminonaphthalene-1-sulfonyl)-L-citrulline; Nδ-Dansyl-L-citrulline; L-Citrulline, N5-[5-(dimethylamino)-1-naphthalenesulfonyl]-; Dns-Cit-OH; DNS-Citrulline
EINECS	Contact for details

Quality Control

Our Dansyl-L-Citrulline is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for sensitive research applications. We provide comprehensive analytical documentation, including Certificates of Analysis (COA) with detailed HPLC purity data, confirming compliance with in-house specifications for research-grade biochemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. The product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	Light yellow to yellow powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.