Description

Arachidonic Acid 5-Hydroperoxide is a specialized bioactive lipid peroxide derived from arachidonic acid, serving as a critical intermediate in the biosynthesis of pro-inflammatory eicosanoids. Its primary value lies in its role as a key research standard for studying oxidative stress pathways, lipoxygenase enzyme activity, and inflammatory mediator formation. This high-purity compound is essential for researchers and developers in the pharmaceutical, biotechnology, and nutraceutical industries, particularly those focused on inflammation, immunology, and cardiovascular disease research.

Application

• Biochemical Research Standard: Used as a certified reference material for the quantification and study of lipid peroxidation products in biological systems.
• Enzymology Studies: Serves as a specific substrate for investigating the kinetics and mechanism of 5-lipoxygenase and related enzymes.
• Inflammation & Immunology Research: A crucial precursor in the synthesis of leukotrienes (e.g., LTA4), making it vital for modeling inflammatory pathways and screening potential anti-inflammatory agents.
• Pharmaceutical Development: Employed in the development and validation of analytical methods (HPLC, LC-MS) for drug discovery programs targeting eicosanoid receptors.
• Oxidative Stress Biomarker: Utilized in assays to measure oxidative damage in cells and tissues, relevant to aging, neurodegenerative diseases, and metabolic disorders.
• Nutraceutical & Cosmetic Science: Applied in research to evaluate the efficacy of antioxidants and natural extracts in inhibiting specific lipid peroxidation pathways.

Basic Information

Product Name	Arachidonic Acid 5-Hydroperoxide
CAS No.	74581-83-2
Molecular Formula	C₂₀H₃₂O₄
Molecular Weight	336.47 g/mol
Synonyms	5(S)-HPETE; 5(S)-Hydroperoxyeicosatetraenoic Acid; (5S)-Hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic Acid; Arachidonic acid 5-hydroperoxide, (5S)-; 5-HPETE; AA 5-HP; 5(S)-HpETE
EINECS	Contact for details

Quality Control

Our Arachidonic Acid 5-Hydroperoxide is produced and handled under strict quality protocols to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We adhere to relevant industry standards for high-purity biochemicals, ensuring material integrity from synthesis to shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen). This product is easily oxidized and moisture-sensitive; allow the sealed vial to equilibrate to room temperature before opening to prevent condensation. Store away from strong acids, bases, and reducing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil or film
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥ 95%
5(S)-HPETE Isomer Purity	≥ 90%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Solvent (Ethanol)	Residual solvent meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.