Description

Bz-Phe-Val-Arg-4Mbetana CAS NO 74503-79-0 is a specialized synthetic peptide derivative, specifically a chromogenic substrate designed for high-precision enzymatic assays. This compound is critical for researchers and quality control laboratories requiring accurate measurement of serine protease activity, particularly thrombin and related enzymes. It is an essential tool for biochemical research, pharmaceutical development, and diagnostic applications where reliable and sensitive detection of enzymatic processes is paramount.

Application

• Biochemical Research: As a chromogenic substrate for kinetic studies and characterization of serine proteases, including thrombin, trypsin, and plasmin.
• Pharmaceutical Development: Used in high-throughput screening (HTS) assays to identify and evaluate potential protease inhibitors for drug discovery programs.
• Diagnostic Manufacturing: A key component in the formulation of clinical diagnostic kits for measuring coagulation factors and other hemostasis parameters.
• Quality Control (QC) Testing: Employed in QC laboratories for the potency testing of biopharmaceuticals like thrombin products and other enzyme-based therapeutics.
• Enzyme Activity Profiling: Facilitates the study of enzyme specificity and catalytic efficiency in complex biological samples.

Basic Information

Product Name	Bz-Phe-Val-Arg-4Mbetana
CAS No.	74503-79-0
Molecular Formula	C34H48N8O6
Molecular Weight	664.80 g/mol
Synonyms	Benzoyl-Phe-Val-Arg-4-Methoxy-2-naphthylamide; Bz-Phe-Val-Arg-4MβNA; Chromogenic Substrate for Thrombin; Bz-F-V-R-4MβNA; Thrombin Substrate I (Chromogenic); N-Benzoyl-L-phenylalanyl-L-valyl-L-arginine 4-methoxy-2-naphthylamide; Boc-Phe-Val-Arg-4MβNA (common abbreviation); L-Phenylalanyl-L-valyl-N-[(1S)-1-[[(4-methoxy-2-naphthalenyl)amino]carbonyl]-4-quanidinobutyl]carbamic acid (S)-phenylmethyl ester
EINECS	Contact for details

Quality Control

Every batch of Bz-Phe-Val-Arg-4Mbetana is manufactured under strict quality management protocols. We guarantee high purity and batch-to-batch consistency through comprehensive analytical testing, including HPLC for purity, mass spectrometry for identity confirmation, and spectrophotometry for functional performance. A Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment to ensure compliance with your research and production standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term stability, store under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, DMF; slightly soluble in water
Functional Activity	≥ 95% of reference standard in thrombin assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.