Description

Mannose, D-, [1-3H] is a high-specific-activity tritium-labeled derivative of D-mannose, a fundamental monosaccharide. This radiolabeled compound is essential for advanced metabolic and biochemical tracer studies, enabling precise tracking and quantification in complex biological systems. It is a critical reagent for researchers in pharmaceutical development, carbohydrate metabolism research, and diagnostic assay development who require reliable, high-purity isotopic labels.

Application

• Biochemical Tracer Studies: Used to investigate the uptake, metabolism, and pharmacokinetics of mannose and mannose-containing compounds in vitro and in vivo.
• Glycobiology Research: Essential for tracing the incorporation of mannose into glycoproteins, glycolipids, and oligosaccharides, aiding in the study of glycosylation pathways.
• Drug Discovery & Development: Serves as a key tool in the development of metabolic inhibitors, glycan-based therapeutics, and diagnostic agents targeting sugar metabolism.
• Enzymology Assays: Employed as a substrate in radiometric assays to study the activity of kinases, isomerases, and other enzymes involved in hexose metabolism.
• Metabolic Disorder Research: Facilitates research into conditions like congenital disorders of glycosylation (CDG) by tracing metabolic flux.
• Membrane Transport Studies: Used to characterize and quantify the function of glucose/mannose transporters (GLUTs, SGLTs) in various cell types.

Basic Information

Product Name	Mannose, D-, [1-3H]
CAS No.	74340-30-0
Molecular Formula	C6H113HO6
Molecular Weight	~181.16 g/mol (for unlabeled form)
Synonyms	D-[1-3H]Mannose; [1-3H]-D-Mannose; Tritiated D-Mannose; D-Mannose-1-t; Mannose (D-, [1-3H]); 1-Tritio-D-mannopyranose; Radiolabeled D-Mannose
EINECS	Contact for details

Quality Control

Every batch of Mannose, D-, [1-3H] is manufactured and analyzed under strict quality systems to ensure identity, purity, and specific activity. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request and provide detailed data on radiochemical purity, specific activity, chemical purity, and solvent composition.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in the original solvent as specified on the label. For long-term storage, keep at -70°C to -80°C. This product is light-sensitive (store away from light) and solutions should be handled with appropriate shielding and laboratory practices for radioactive materials.

Specification

Item	Specification
Appearance	Clear, colorless solution
Chemical Purity (HPLC)	≥ 98%
Radiochemical Purity (HPLC)	≥ 97%
Specific Activity	10-40 Ci/mmol (Contact for exact value)
Identification (IR/NMR)	Conforms to structure
Solvent	Ethanol:Water (9:1) or as specified
Concentration	1 mCi/mL (Nominal)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.