Description

Calcium Ionophore II is a highly selective ion carrier compound used to transport calcium ions across biological membranes. This compound is critical for modulating intracellular calcium concentrations in experimental settings, serving as a powerful research tool. It is primarily utilized by researchers and scientists in the fields of cell biology, neurobiology, and pharmacology for studying calcium signaling pathways, ion channel function, and cellular physiology.

Application

• Intracellular Calcium Modulation: Used as a research tool to artificially raise cytosolic calcium levels in cell culture and tissue studies.
• Signal Transduction Research: Essential for investigating calcium's role as a secondary messenger in various cellular processes.
• Neuroscience Studies: Applied in experiments to study calcium-dependent neurotransmitter release and neuronal excitability.
• Cardiovascular Research: Utilized to examine calcium-induced muscle contraction and regulation in cardiac and smooth muscle cells.
• Pharmacological Screening: Serves as a control or challenge agent in assays designed to discover new calcium channel blockers or modulators.
• Fluorescence Imaging Calibration: Used in conjunction with calcium-sensitive fluorescent dyes (e.g., Fura-2, Fluo-4) to calibrate and validate imaging systems.

Basic Information

Product Name	Calcium Ionophore II
CAS No.	74267-27-9
Molecular Formula	C29H37N3O6
Molecular Weight	523.62 g/mol
Synonyms	Calcimycin, Antibiotic A23187; A23187, Calcium Ionophore A23187; 4-Bromo-A23187; 5-(Methylamino)-2-[[(2S,3R,5S,6R,8S,9R)-3,5,9-trimethyl-8-[(1R)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl]-1,7-dioxaspiro[5.5]undec-2-yl]methyl]-1,3-benzoxazole-4-carbonitrile
EINECS	Contact for details

Quality Control

Our Calcium Ionophore II is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity verification and structural confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and performance. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Solubility	Soluble in DMSO, ethanol, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.