Description

1-(5'-Hydroxyhexylcarbamoyl)-5-Fluorouracil is a chemically modified derivative of the classic antimetabolite 5-fluorouracil (5-FU), designed to improve pharmacokinetic properties and target specificity. This compound is significant for its potential as a prodrug in advanced pharmaceutical research and development, offering a pathway to enhance therapeutic efficacy while mitigating systemic toxicity. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel oncology therapeutics, targeted drug delivery systems, and prodrug strategies.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel anticancer prodrugs and targeted therapies.
• Oncology Research: Used in preclinical studies to investigate improved delivery mechanisms for fluoropyrimidine-based chemotherapy.
• Prodrug Development: Acts as a model compound for designing molecules with enhanced tumor selectivity and reduced side-effect profiles.
• Bioconjugation Studies: Utilized in research focusing on linking cytotoxic agents to antibodies, peptides, or polymers for targeted delivery.
• Chemical Biology: Employed as a tool compound to study nucleotide metabolism and the mechanisms of action of fluorouracil derivatives.
• API Synthesis: Functions as a sophisticated intermediate in the multi-step synthesis of complex active pharmaceutical ingredients (APIs).

Basic Information

Product Name	1-(5'-Hydroxyhexylcarbamoyl)-5-Fluorouracil
CAS No.	74173-52-7
Molecular Formula	C12H18FN3O4
Molecular Weight	287.29 g/mol
Synonyms	5-Fluoro-1-[(5-hydroxyhexyl)carbamoyl]uracil; 1-[(5-Hydroxyhexyl)carbamoyl]-5-fluorouracil; 5-FU-C6-OH; N1-(5-Hydroxyhexylcarbamoyl)-5-fluorouracil; 1-Carbamoyl-5-fluorouracil hexanol derivative; HHC-FU
EINECS	Contact for details

Quality Control

Our 1-(5'-Hydroxyhexylcarbamoyl)-5-Fluorouracil is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); therefore, the container should be kept tightly sealed in a dry environment. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay	97.0% - 102.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.