Description

11-Thiohomoaminopterin is a chemically modified analog of the classical antifolate aminopterin, distinguished by the incorporation of a sulfur atom. This structural modification is of significant interest in medicinal chemistry and biochemical research for exploring structure-activity relationships and developing novel therapeutic agents. It serves as a critical research chemical for scientists in pharmaceutical R&D and academic institutions focused on oncology, enzymology, and targeted drug discovery.

Application

• Biochemical Research: Used as a specialized tool compound to study the mechanism and inhibition of dihydrofolate reductase (DHFR) and other folate-dependent enzymes.
• Pharmaceutical Development: Acts as a key intermediate or reference standard in the discovery and synthesis of novel antifolate chemotherapeutic agents.
• Oncology Studies: Employed in in vitro and cellular assays to investigate antiproliferative effects and potential pathways for cancer treatment.
• Enzyme Kinetics: Utilized to determine inhibitory constants (Ki) and understand the binding interactions within enzyme active sites.
• Academic Research: Serves as a valuable compound for universities and research institutes conducting studies in medicinal chemistry and molecular biology.
• Reference Standard: Provides a high-purity benchmark for analytical method development, validation, and quality control of related compounds.

Basic Information

Product Name	11-Thiohomoaminopterin
CAS No.	74163-10-3
Molecular Formula	C20H23N7O5S
Molecular Weight	473.51 g/mol
Synonyms	11-Thiohomoaminopterin; 4-Amino-10-methylpteroyl-11-thiahomoglutamic Acid; 11-Thiahomofolic Acid Amide; N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]amino]benzoyl]-11-thiahomoglutamic Acid; 11-Thia-aminopterin; Thiohomoaminopterin; Aminopterin 11-Thia Homolog
EINECS	Contact for details

Quality Control

Our 11-Thiohomoaminopterin is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.