Description

Leukotriene D4 is a potent cysteinyl leukotriene (CysLT) and a key inflammatory mediator derived from arachidonic acid metabolism. It plays a critical role in the pathophysiology of asthma, allergic rhinitis, and other inflammatory conditions by inducing bronchoconstriction, vascular permeability, and mucus secretion. This makes it an essential reference standard and research tool for pharmaceutical R&D, clinical diagnostics, and academic studies focused on respiratory and immunological diseases.

Application

• Pharmaceutical Reference Standard: Primary use as a certified standard for analytical method development, validation, and quality control in drug discovery and manufacturing, particularly for leukotriene receptor antagonist (LTRA) drugs like montelukast.
• Biomedical Research: Critical reagent for in vitro and ex vivo studies investigating the mechanisms of asthma, anaphylaxis, and chronic inflammatory diseases.
• Drug Discovery & Screening: Used in high-throughput screening (HTS) assays to identify and evaluate potential new anti-inflammatory compounds and LTRA candidates.
• Clinical Diagnostics Development: Employed in the development of immunoassays (e.g., ELISA) to measure leukotriene levels in biological samples for clinical research.
• Academic & Institutional Research: Fundamental tool for university and research institute labs studying eicosanoid biology, signal transduction pathways, and inflammatory mediators.
• Toxicology Studies: Used to assess compound toxicity and inflammatory responses in preclinical research models.

Basic Information

Product Name	Leukotriene D4
CAS No.	73836-78-9
Molecular Formula	C25H40N2O7S
Molecular Weight	496.66 g/mol
Synonyms	LTD4; Leukotriene D4; (5S,6R)-7-[(1R,2E,4E,6Z,9Z)-1-[(2S)-2-Amino-2-carboxyethyl]sulfanyl-2,4,6,9-heptadecatetraenyl]sulfanyl-5,6-epoxyoxepan-2-one; 5(S)-Hydroxy-6(R)-S-cysteinylglycyl-7,9-trans-11,14-cis-eicosatetraenoic Acid; 5-Hydroxy-6-S-cysteinylglycyl-7,9,11,14-eicosatetraenoic Acid
EINECS	Contact for details

Quality Control

Our Leukotriene D4 is produced and handled under strict quality management protocols to ensure the highest standards of purity and batch-to-batch consistency, suitable for sensitive research and analytical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We adhere to relevant guidelines for reference standard materials to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere. The product is light-sensitive and easily oxidized; allow it to reach room temperature in a desiccator before opening to minimize moisture uptake and oxidative degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.