Description

2-Deoxy-D-Glucose, [3H(G)] CAS NO 73698-45-0 is a radiolabeled analog of glucose where tritium atoms are incorporated at specific positions, enabling precise metabolic tracing. This compound is a critical tool for investigating glucose uptake, metabolism, and the Warburg effect in cancer cells and other metabolic studies. It is essential for researchers and scientists in the fields of radiopharmaceutical development, oncology research, and biochemistry. The tritiated label provides a safe and effective means for autoradiography, competitive binding assays, and detailed pharmacokinetic profiling.

Application

• Metabolic Pathway Research: Tracing and quantifying glucose uptake and utilization in normal and diseased cells.
• Oncology Studies: Investigating the altered glucose metabolism (aerobic glycolysis) characteristic of cancer cells (the Warburg effect).
• Drug Discovery & Development: Serving as a tracer in assays to screen for potential therapeutic agents that target glucose metabolism.
• Neurological Research: Studying brain energy metabolism and glucose transport across the blood-brain barrier.
• Autoradiography: Used for spatial visualization of glucose analog distribution in tissue sections.
• Biochemical Assays: Acting as a substrate or inhibitor in enzymatic studies related to hexokinase and glycolysis.

Basic Information

Product Name	2-Deoxy-D-Glucose, [3H(G)]
CAS No.	73698-45-0
Molecular Formula	C6H11TO5 *
Molecular Weight	~165.2 g/mol (unlabeled) *
Synonyms	2-Deoxy-D-[3H]glucose; 2-DG-[3H]; D-[3H]-2-Deoxyglucose; Tritiated 2-Deoxy-D-glucose; 2-Deoxy-D-arabino-hexose, tritiated; Radioactive 2-DG; Metabolic tracer 2-DG; [3H]-2DG
EINECS	Contact for details

* Molecular weight is approximate and varies with specific activity and tritiation position. Exact values are provided on the Certificate of Analysis.

Quality Control

Every batch of 2-Deoxy-D-Glucose, [3H(G)] is manufactured and handled under strict quality protocols to ensure radiochemical purity, specific activity, and chemical stability. Comprehensive analysis is performed, including HPLC for radiochemical purity determination and liquid scintillation counting for accurate specific activity measurement. A detailed Certificate of Analysis (COA), specifying batch-specific data such as purity, concentration, solvent, and expiration date, is provided with each shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at or below -20°C in the original solvent as specified on the label and COA. For long-term stability, solutions should be kept in amber vials or vials wrapped in aluminum foil to minimize light exposure. Always follow local regulations for the safe storage and handling of radioactive materials.

Specification

Item	Specification
Appearance	Clear, colorless to slightly yellow solution
Specific Activity	10-50 Ci/mmol (Contact for specific batch data)
Radiochemical Purity (HPLC)	≥ 95%
Concentration	1 mCi/mL in ethanol:water (9:1) or as specified
Chemical Purity (HPLC)	≥ 98%
Solvent	Ethanol:Water (9:1) or custom

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.