Description

Cortisol-21-3-Maleimidobenzoate is a high-purity, chemically modified derivative of cortisol (hydrocortisone) designed for advanced bioconjugation and research applications. This compound is engineered to facilitate the covalent attachment of cortisol to proteins, peptides, or other biomolecules via its maleimide functional group, enabling precise targeting and study of glucocorticoid pathways. It is an essential tool for researchers and developers in the fields of pharmaceutical discovery, biochemical assay development, and targeted drug delivery systems.

Application

• Bioconjugation Reagent: For the site-specific labeling of thiol-containing proteins, antibodies, or peptides with a cortisol moiety for immunoassays and targeted therapies.
• Pharmaceutical Research: Used in the development of novel drug conjugates and prodrugs that target glucocorticoid receptors.
• Biochemical Tool Compound: Essential for studying cortisol-mediated signaling pathways, receptor binding, and intracellular trafficking in research settings.
• Diagnostic Kit Development: A key intermediate in the synthesis of labeled tracers and antigens for competitive ELISA and other immunoassay platforms.
• Proteomics and Biomarker Studies: Enables the covalent immobilization of cortisol for affinity purification or surface plasmon resonance (SPR) studies to investigate protein-hormone interactions.
• Material Science: Can be used to functionalize surfaces or nanoparticles for biosensor applications and controlled release systems.

Basic Information

Product Name	Cortisol-21-3-Maleimidobenzoate
CAS No.	73499-12-4
Molecular Formula	C₃₂H₃₇NO₇
Molecular Weight	547.65 g/mol
Synonyms	Hydrocortisone 21-(3-maleimidobenzoate); 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione 21-[3-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)benzoate]; Cortisol Maleimidobenzoate; Cortisol-3-Maleimidobenzoate; Hydrocortisone Maleimidobenzoate Ester; 1H-Pyrrole-1-propanoic acid, 2,5-dihydro-2,5-dioxo-, 3-[(11β,17α,21-trihydroxypregn-4-ene-3,20-dione-21-yl)oxy]carbonyl]phenyl ester; Glucocorticoid Maleimide Conjugate
EINECS	Contact for details

Quality Control

Our Cortisol-21-3-Maleimidobenzoate is manufactured under strict quality protocols to ensure high purity and batch-to-batch consistency suitable for sensitive research applications. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.