Description

Tos-Gly-Pro-Lys-Pna CAS NO 73392-19-5 is a specialized synthetic peptide substrate, specifically a chromogenic p-nitroanilide (pNA) derivative. This compound is of significant value in biochemical and pharmaceutical research for its role in studying enzyme kinetics and inhibition profiles. It is primarily utilized by research institutions, diagnostic kit manufacturers, and pharmaceutical companies involved in protease and peptidase assay development.

Application

• Enzyme Substrate for Protease Research: Used as a specific chromogenic substrate to measure the activity of various serine and cysteine proteases in kinetic assays.
• Biochemical Assay Development: A critical component in developing high-throughput screening (HTS) assays for drug discovery targeting proteolytic enzymes.
• Diagnostic Reagent Manufacturing: Employed in the formulation of diagnostic kits for clinical research to detect and quantify specific enzyme activities.
• Mechanistic Studies: Facilitates the study of enzyme mechanism of action (MOA) and the evaluation of inhibitor potency (IC50 determination).
• Quality Control in Biologics: Used to monitor the presence and activity of specific proteases during the production and purification of biopharmaceuticals.

Basic Information

Product Name	Tos-Gly-Pro-Lys-Pna
CAS No.	73392-19-5
Molecular Formula	C27H35N7O7S
Molecular Weight	601.67 g/mol
Synonyms	Tosyl-Glycyl-Prolyl-Lysine p-nitroanilide; Tos-Gly-Pro-Lys-pNA; H-Tos-Gly-Pro-Lys-pNA; Chromogenic Substrate for Proteases; pNA Substrate; Nα-Tosyl-Glycyl-L-prolyl-L-lysine 4-nitroanilide acetate salt; Protease Substrate 73392-19-5
EINECS	Contact for details

Quality Control

Our Tos-Gly-Pro-Lys-Pna is produced under stringent quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing including HPLC for purity, MS for identity confirmation, and NMR for structural verification. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.