Description

1-n-(2-Aminoethoxycarbonyl)Kanamycin A is a chemically modified derivative of the aminoglycoside antibiotic Kanamycin A, designed for enhanced functionality in advanced research and development. This semi-synthetic compound is critical for scientists developing novel conjugates, targeted drug delivery systems, and biochemical probes. It is primarily utilized by researchers and developers in the pharmaceutical, biotechnology, and life sciences sectors for creating next-generation therapeutic and diagnostic agents.

Application

• Pharmaceutical Intermediate: Serves as a key building block for the synthesis of novel antibiotic conjugates and prodrugs with improved targeting or reduced toxicity.
• Bioconjugation & Probe Development: Used to create fluorescent, radioactive, or affinity-labeled probes for studying bacterial ribosomes, antibiotic mechanisms of action, and cellular uptake.
• Antibiotic Research: Acts as a core structure for structure-activity relationship (SAR) studies aimed at overcoming bacterial resistance mechanisms.
• Targeted Drug Delivery Systems: The reactive aminoethoxycarbonyl group facilitates covalent attachment to antibodies, nanoparticles, or polymers for site-specific antibiotic delivery.
• Biochemical Tool Compound: Employed in enzymatic studies and as a selective inhibitor in molecular biology research.

Basic Information

Product Name	1-n-(2-Aminoethoxycarbonyl)Kanamycin A
CAS No.	73352-74-6
Molecular Formula	C24H46N6O14
Molecular Weight	642.66 g/mol
Synonyms	Kanamycin A 1-N-(2-Aminoethoxycarbonyl) Derivative; 1-N-[(2-Aminoethoxy)carbonyl]kanamycin A; 1-N-(Aminoethoxycarbonyl)kanamycin; Kanamycin A Carbamate Derivative; 1-N-Carbamoylkanamycin A Derivative; 6-O-(3-Amino-3-deoxy-α-D-glucopyranosyl)-4-O-(6-amino-6-deoxy-α-D-glucopyranosyl)-2-deoxy-N1-(2-aminoethoxycarbonyl)-D-streptamine; 73352-74-6
EINECS	Contact for details

Quality Control

Every batch of 1-n-(2-Aminoethoxycarbonyl)Kanamycin A is manufactured and tested under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure compliance with research-grade specifications. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Bacterial Endotoxins	< 1.0 EU/mg (if applicable)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.