Description

S-(p-Azidophenacyl)Glutathione is a specialized, photoactivatable biochemical reagent designed for affinity labeling and cross-linking studies. This compound matters for researchers as it provides a precise tool for mapping protein active sites and studying enzyme mechanisms through covalent modification. It is primarily needed by scientists in pharmaceutical R&D, proteomics, and biochemistry for investigating glutathione-dependent pathways and protein-ligand interactions.

Application

• Affinity Labeling of Enzymes: Used as a photoaffinity probe to covalently tag and identify glutathione S-transferase (GST) active sites and other glutathione-binding proteins.
• Proteomics Research: Employed in the study of protein-protein interactions and the structural mapping of binding pockets within complex biological systems.
• Mechanistic Biochemistry: Aids in elucidating reaction mechanisms of enzymes that utilize glutathione as a cofactor or substrate.
• Bioconjugation & Cross-linking: Serves as a heterobifunctional cross-linker for attaching molecules to proteins or surfaces for analytical and diagnostic applications.
• Drug Discovery: Utilized in target identification and validation studies for therapies targeting oxidative stress and detoxification pathways.

Basic Information

Product Name	S-(p-Azidophenacyl)Glutathione
CAS No.	73322-71-1
Molecular Formula	C20H26N6O7S
Molecular Weight	494.52 g/mol
Synonyms	S-(4-Azidophenacyl)glutathione; Glutathione S-(p-azidophenacyl) ester; 4-Azidophenacyl glutathione thioether; N-(N-L-γ-Glutamyl-L-cysteinyl)glycine S-(4-azidophenacyl) ester; Photoaffinity glutathione derivative; APG; Azidophenacyl-GSH
EINECS	Contact for details

Quality Control

Our S-(p-Azidophenacyl)Glutathione is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity verification and structural confirmation via spectroscopic methods. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This compound is light-sensitive and should be handled under subdued lighting conditions to preserve its photoaffinity properties. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.