Description

Apraclonidine Hydrochloride is a selective α-2 adrenergic receptor agonist, widely recognized for its potent pharmacological activity. This compound is of critical importance in the pharmaceutical industry for the development and manufacturing of specialized ophthalmic solutions. It is primarily required by pharmaceutical manufacturers, research institutions, and contract development organizations engaged in creating treatments for glaucoma and during ophthalmic surgical procedures.

Application

• Ophthalmic Pharmaceutical Manufacturing: Primary active pharmaceutical ingredient (API) in prescription eye drops for lowering intraocular pressure (IOP) in patients with glaucoma.
• Surgical Adjunct: Used to prevent or manage IOP spikes during and after laser surgical procedures on the eye, such as laser trabeculoplasty or iridotomy.
• Pharmaceutical Research & Development: Serves as a key reference standard and intermediate in preclinical and clinical studies targeting α-2 adrenergic pathways.
• Generic Drug Formulation: Essential for companies developing bioequivalent versions of branded apraclonidine hydrochloride ophthalmic solutions.
• Analytical Testing: Used as a high-purity certified reference material (CRM) in quality control laboratories for HPLC, LC-MS, or spectroscopic assay methods.
• Chemical Synthesis: Acts as a crucial synthetic intermediate or starting material for the preparation of novel derivatives with potential therapeutic applications.

Basic Information

Item	Detail
Product Name	Apraclonidine Hydrochloride
CAS No.	73218-79-8
Molecular Formula	C9H11Cl2N3
Molecular Weight	244.11 g/mol
Synonyms	p-Aminoclonidine Hydrochloride; Iopidine (brand name); AL-02145; UK-14,304-18; 2-[(4-Amino-2,6-dichlorophenyl)imino]imidazolidine Hydrochloride; N-(4-Amino-2,6-dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine Hydrochloride; APC; Apraclonidine HCl
EINECS	Contact for details

Quality Control

Our Apraclonidine Hydrochloride is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including identification, assay, and impurity profiling via HPLC, to ensure it meets stringent pharmaceutical-grade specifications. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability, purity, and compliance with relevant guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a low-humidity environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.