Description

(5E,8E,11E,13E)-15-Hydroxyicosa-5,8,11,13-Tetraenoic Acid CAS NO 73180-00-4 is a high-purity, long-chain polyunsaturated fatty acid derivative, specifically a 15-hydroxyeicosatetraenoic acid (15-HETE) isomer. This compound is a significant bioactive lipid mediator involved in various physiological and pathological processes, making it a critical reference standard and research chemical. It is essential for researchers and developers in the pharmaceutical and life sciences sectors who require precise, well-characterized molecules for biochemical studies, drug discovery, and analytical method development.

Application

• Biochemical Research: Used as a reference standard and substrate in studies of lipoxygenase pathways, eicosanoid biosynthesis, and inflammation mechanisms.
• Pharmaceutical Development: Serves as a key intermediate or analytical standard in the research and development of anti-inflammatory and immunomodulatory therapeutics.
• Cell Signaling Studies: Employed to investigate the role of specific HETE isomers in cellular signaling, proliferation, and apoptosis.
• Analytical Chemistry: Acts as a high-purity calibrant for quantitative analysis using techniques like HPLC, LC-MS, and GC-MS in metabolomics and lipidomics.
• Enzymology: Utilized as a specific substrate for studying the activity and inhibition of 15-lipoxygenase enzymes.
• Academic Research: A vital tool for universities and research institutes exploring the complex biology of oxylipins and their metabolic pathways.

Basic Information

Product Name	(5E,8E,11E,13E)-15-Hydroxyicosa-5,8,11,13-Tetraenoic Acid
CAS No.	73180-00-4
Molecular Formula	C₂₀H₃₂O₃
Molecular Weight	320.47 g/mol
Synonyms	15(S)-HETE; 15-Hydroxyeicosatetraenoic Acid; (15S)-15-Hydroxy-5Z,8Z,11Z,13E-eicosatetraenoic Acid; 15(S)-HETE; 15S-Hydroxy-5,8,11,13-eicosatetraenoic Acid; 15-HETE; 15-Hydroxy-5,8,11,13-eicosatetraenoic Acid; 15S-HETE
EINECS	Contact for details

Quality Control

Our (5E,8E,11E,13E)-15-Hydroxyicosa-5,8,11,13-Tetraenoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the product to reach room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Assay	≥ 90% (by weight)
Solubility	Soluble in ethanol, DMSO, methanol; insoluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.