Description

8-Hydroxyeicosatetraenoic Acid (8-HETE) is a specialized bioactive lipid mediator derived from arachidonic acid metabolism. This compound is of significant interest in biochemical and pharmacological research due to its role as a signaling molecule in various inflammatory and cellular pathways. It is primarily utilized by researchers and developers in the pharmaceutical, biotechnology, and life sciences sectors for target validation, assay development, and mechanistic studies.

Application

• Biochemical Research: Used as a reference standard and analytical tool in the study of eicosanoid pathways and lipidomics.
• Pharmacological Studies: Employed to investigate the role of hydroxyeicosatetraenoic acids (HETEs) in inflammation, cell proliferation, and signal transduction mechanisms.
• Drug Discovery & Development: Serves as a key intermediate or target molecule in the development of novel anti-inflammatory and metabolic disorder therapeutics.
• Diagnostic Assay Development: Utilized in the calibration and validation of ELISA, LC-MS, and other analytical methods for eicosanoid quantification.
• Academic Research: A critical reagent for universities and research institutes studying cardiovascular biology, oncology, and immunology.

Basic Information

Product Name	8-Hydroxyeicosatetraenoic Acid
CAS No.	73179-96-1
Molecular Formula	C₂₀H₃₂O₃
Molecular Weight	320.47 g/mol
Synonyms	8-HETE; 8(S)-HETE; 8-Hydroxy-5Z,9E,11Z,14Z-eicosatetraenoic Acid; (8S)-8-Hydroxyicosa-5Z,9E,11Z,14Z-tetraenoic Acid; 8-Hydroxyeicosatetraenoic Acid; 8(S)-Hydroxyeicosatetraenoic Acid; Arachidonic Acid, 8-hydroxy-; 8-Hydroxy-5,9,11,14-eicosatetraenoic Acid
EINECS	Contact for details

Quality Control

Our 8-Hydroxyeicosatetraenoic Acid is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the high standards required for research applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the vial to reach room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil or film
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95% (Area %)
Isomeric Purity (Chiral HPLC)	≥ 90% (8S-isomer)
Solubility	Soluble in ethanol, DMSO, and dimethyl formamide

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.