Description

R-Methylmalonyl-Coa is a crucial biochemical coenzyme derivative, specifically the (R)-enantiomer of methylmalonyl-coenzyme A. This high-purity intermediate is essential for research and development in metabolic pathways, particularly those involving propionate metabolism and vitamin B12-dependent reactions. It serves as a vital substrate for enzymologists, pharmaceutical researchers, and biochemists working on inborn errors of metabolism, antibiotic biosynthesis, and advanced biocatalysis.

Application

• Enzymology Research: Critical substrate for studying methylmalonyl-CoA mutase, methylmalonyl-CoA epimerase, and other enzymes in the methylmalonyl-CoA pathway.
• Metabolic Disorder Studies: Used in research models for Methylmalonic Acidemia (MMA) and other propionic acidemias to understand disease mechanisms and screen potential therapeutics.
• Pharmaceutical Development: Serves as a biochemical tool in the development of inhibitors and modulators for metabolic enzymes, relevant to antibiotic and metabolic disease drug discovery.
• Biocatalysis & Synthesis: Employed as a building block in enzymatic synthesis for producing chiral compounds and complex natural products.
• Diagnostic Reagent Manufacturing: Used in the formulation of assay kits and reagents for clinical diagnostics targeting metabolic enzyme deficiencies.
• Academic & Institutional Research: Fundamental reagent for university and government labs investigating intermediary metabolism and coenzyme A-dependent biochemistry.

Basic Information

Product Name	R-Methylmalonyl-Coa
CAS No.	73173-92-9
Molecular Formula	C25H40N7O19P3S
Molecular Weight	867.60 g/mol
Synonyms	(R)-Methylmalonyl-Coenzyme A; (R)-Methylmalonyl-CoA; (2R)-2-Methyl-3-oxopropanoyl-CoA; Methylmalonyl-CoA (R-form); S-Methylmalonyl-CoA (obsolete name); MM-CoA; Coenzyme A, S-[(2R)-2-methyl-3-oxo-1-oxopropoxy-2,3-dihydroxy-4-phosphobutyl-N-(7-fluoro-4-quinolinyl)-L-threonamide] (systematic); 2-Methyl-3-oxopropanoyl-CoA (R-enantiomer)
EINECS	Contact for details

Quality Control

Every batch of R-Methylmalonyl-Coa is manufactured and analyzed under strict quality protocols to ensure identity, purity, and biochemical activity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing results from HPLC, NMR, and MS analysis. Our quality system is designed to support GLP (Good Laboratory Practice) and research-grade applications, ensuring reliable and reproducible performance for your critical experiments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and easily oxidized. For long-term stability, store desiccated. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder or lyophilized solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Enantiomeric Purity	≥ 98% (R)
Water Content (KF)	≤ 3.0%
Biological Activity	Tested as suitable substrate for methylmalonyl-CoA mutase

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.