Description

Prolyl-Phenylalanyl-Arginine Naphthylester is a synthetic peptide derivative and chromogenic substrate designed for specific enzymatic activity detection. This compound is valued for its role as a highly selective and sensitive reagent in biochemical research and diagnostic assay development. It is primarily needed by research institutions, pharmaceutical R&D laboratories, and diagnostic kit manufacturers working in the fields of protease enzymology and clinical diagnostics.

Application

• Protease Substrate: Used as a specific chromogenic substrate for the detection and quantification of trypsin, thrombin, and other serine proteases.
• Biochemical Research: Essential for kinetic studies, enzyme inhibition assays, and characterizing protease specificity in academic and pharmaceutical research.
• Diagnostic Assays: Incorporated into in vitro diagnostic (IVD) kits for measuring protease activity in clinical samples, relevant to conditions like pancreatitis or coagulation disorders.
• Quality Control Reagent: Employed in biopharmaceutical manufacturing for monitoring the activity and purity of enzyme-based therapeutics.
• High-Throughput Screening (HTS): Serves as a key component in HTS platforms for drug discovery programs targeting proteases.

Basic Information

Product Name	Prolyl-Phenylalanyl-Arginine Naphthylester
CAS No.	73142-64-0
Molecular Formula	C₃₀H₃₈N₆O₆
Molecular Weight	578.66 g/mol
Synonyms	Pro-Phe-Arg-β-naphthyl ester; Pro-Phe-Arg-βNA; H-Pro-Phe-Arg-β-naphthyl ester; Tosyl-Gly-Pro-Arg-2-naphthyl ester (related); Chromogenic substrate for trypsin; Trypsin chromogenic substrate; Serine protease substrate 73142-64-0; PFAN
EINECS	Contact for details

Quality Control

Our Prolyl-Phenylalanyl-Arginine Naphthylester is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for research and diagnostic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and performance in standardized enzymatic assays. We adhere to relevant quality guidelines suitable for research and in vitro diagnostic use.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and performance. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Specific Optical Rotation	Contact for details
Enzymatic Activity	Conforms to reference standard
Solubility	Soluble in DMSO, DMF; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.