Description

(S)-Nicotine Citrate CAS NO 73086-01-8 is the citrate salt of the (S)-enantiomer of nicotine, a high-purity chiral alkaloid. This specific enantiomeric form is critical for research and applications requiring precise biological activity, as it is the naturally occurring and pharmacologically active isomer. It is an essential reference standard and intermediate for pharmaceutical research, analytical laboratories, and the development of nicotine replacement therapies and other bioactive compounds.

Application

• Pharmaceutical Reference Standard: Used as a primary standard for the calibration of analytical instruments (HPLC, GC-MS) and for quality control testing of nicotine-containing products.
• Biochemical Research: Employed in neuroscience and pharmacology studies to investigate nicotinic acetylcholine receptor (nAChR) function, addiction mechanisms, and neuroprotection.
• Nicotine Replacement Therapy (NRT) Development: Serves as a key active pharmaceutical ingredient (API) intermediate in the formulation of gums, patches, lozenges, and inhalers.
• Analytical Chemistry: Utilized for method development and validation in the accurate quantification of nicotine in various matrices, including botanicals, e-liquids, and biological samples.
• Agrochemical Research: Acts as a model compound or starting material for developing novel insecticides and pesticides based on nicotinoid chemistry.

Basic Information

Product Name	(S)-Nicotine Citrate
CAS No.	73086-01-8
Molecular Formula	C10H14N2•C6H8O7
Molecular Weight	396.39 g/mol
Synonyms	(-)-Nicotine Citrate; (S)-(-)-Nicotine Citrate; L-Nicotine Citrate; Nicotine Citrate Salt; Nicotine Hydrogen Citrate; 3-[(2S)-1-Methylpyrrolidin-2-yl]pyridine citrate; Citric acid - nicotine (1:1)
EINECS	Contact for details

Quality Control

Our (S)-Nicotine Citrate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets stringent specifications for pharmaceutical and research use. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0% (anhydrous basis)
Chiral Purity (HPLC)	≥ 99.0% (S)-isomer
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.