Description

2-Azidoadenosine 5'-Triphosphate is a chemically modified nucleotide analog that serves as a critical reagent in bioorthogonal chemistry and nucleic acid research. Its value lies in the azido functional group, which enables highly specific, copper-free click chemistry reactions for labeling and crosslinking applications. This compound is essential for researchers and manufacturers in pharmaceutical development, proteomics, and molecular biology, particularly for studying nucleotide-binding proteins and developing targeted diagnostic tools.

Application

• Bioorthogonal Labeling: Used as a substrate for copper-free click chemistry to label ATP-binding proteins and enzymes in live cells.
• Proteomics Research: Enables the identification and isolation of adenosine triphosphate (ATP)-interacting proteins through affinity purification.
• Enzyme Activity Studies: Acts as a photoaffinity probe or an activity-based probe for kinases, ATPases, and other ATP-utilizing enzymes.
• Nucleic Acid Modification: Facilitates the site-specific incorporation of functional groups into RNA or DNA sequences for downstream conjugation.
• Drug Discovery: Employed in high-throughput screening assays to identify novel inhibitors of ATP-dependent biological pathways.
• Diagnostic Development: Serves as a key component in the development of assays for detecting specific enzymatic activities relevant to disease states.

Basic Information

Product Name	2-Azidoadenosine 5'-Triphosphate
CAS No.	72884-75-4
Molecular Formula	C10H14N8O13P3
Molecular Weight	571.14 g/mol
Synonyms	2-Azido-ATP; 2-N3-ATP; 2-Azidoadenosine triphosphate; Adenosine 5'-(tetrahydrogen triphosphate), 2-azido-; 2-Azido-adenosine-5'-triphosphate; γ-Azido-ATP (common misnomer); 2-Azido-1,9-dihydro-9-β-D-ribofuranosyl-6H-purin-6-one 5'-(trihydrogen triphosphate)
EINECS	Contact for details

Quality Control

Every batch of 2-Azidoadenosine 5'-Triphosphate is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and performance. Our quality assurance protocols are designed to meet the exacting standards of research and development. A comprehensive Certificate of Analysis (COA) detailing purity (typically ≥95% by HPLC), identity confirmation, and impurity profile is provided with each shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term stability, it is recommended to store desiccated under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0 %
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.