Description

Di-(4-Toluoyl)-L-Tartaric Anhydride is a high-purity chiral resolving agent and key synthetic intermediate derived from L-tartaric acid. This compound is critically important for the separation of enantiomers in pharmaceutical and fine chemical synthesis, ensuring the production of single-isomer active pharmaceutical ingredients (APIs). It is primarily needed by manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise chiral discrimination and high chemical purity for their processes.

Application

• Chiral Resolution Agent: Used for the optical resolution of racemic mixtures, particularly amines and amino acids, in pharmaceutical intermediate synthesis.
• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of enantiomerically pure drugs and active pharmaceutical ingredients (APIs).
• Asymmetric Synthesis Catalyst Precursor: Employed in the preparation of chiral ligands and catalysts for asymmetric hydrogenation and other stereoselective reactions.
• Analytical Chemistry: Utilized as a chiral derivatizing agent for HPLC and other chromatographic methods to separate and analyze enantiomers.
• Agrochemical Synthesis: Applied in the production of chiral pesticides and herbicides where specific stereochemistry is required for biological activity.
• Fine Chemical Production: Used in the manufacture of specialty chemicals, flavors, and fragrances that demand high enantiomeric purity.

Basic Information

Product Name	Di-(4-Toluoyl)-L-Tartaric Anhydride
CAS No.	72842-25-2
Molecular Formula	C22H20O8
Molecular Weight	412.39 g/mol
Synonyms	Di-p-Toluoyl-L-tartaric Anhydride; (2R,3R)-2,3-Bis(4-methylbenzoyloxy)succinic Anhydride; L-DTTA Anhydride; D-(-)-Di-p-Toluoyltartaric Anhydride; (2R,3R)-2,3-Bis[(4-methylphenyl)carbonyloxy]butanedioic Anhydride; Anhydride of Di-p-Toluoyl-L-tartaric Acid; Chiral Resolving Agent DTTA Anhydride; 72842-25-2
EINECS	Contact for details

Quality Control

Our Di-(4-Toluoyl)-L-Tartaric Anhydride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity (enantiomeric excess) and chemical purity assays, to ensure it meets the high standards required for chiral synthesis and resolution. Certificates of Analysis (COA) with detailed HPLC, NMR, and optical rotation data are provided to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.