Description

Dapiprazole Hydrochloride is a selective α-1 adrenergic receptor antagonist of significant pharmaceutical importance. Its primary value lies in its ability to rapidly reverse pharmacologically-induced mydriasis, making it a critical agent in ophthalmic procedures. This compound is essential for manufacturers and research institutions focused on developing and producing ophthalmic diagnostic and therapeutic solutions. Its targeted action ensures patient comfort and safety following eye examinations involving pupil dilation.

Application

• Ophthalmic Solutions: Key active ingredient in eye drops specifically formulated to reverse mydriasis (pupil dilation) induced by agents like tropicamide or phenylephrine.
• Diagnostic Aid: Used in clinical settings to facilitate the rapid return of the pupil to its normal size after ophthalmic examinations, improving patient recovery time.
• Pharmaceutical Intermediates: Serves as a crucial building block or reference standard in the synthesis and research of other adrenergic receptor-modulating drugs.
• Research & Development: Utilized in preclinical and clinical studies investigating α-1 adrenergic receptor function and related therapeutic pathways.
• Quality Control Standards: Employed as a high-purity reference standard for analytical testing and method validation in pharmaceutical quality assurance laboratories.

Basic Information

Item	Detail
Product Name	Dapiprazole Hydrochloride
CAS No.	72822-13-0
Molecular Formula	C19H27N5O · HCl
Molecular Weight	401.92 g/mol
Synonyms	Dapiprazole HCl; 5,6,7,8-Tetrahydro-3-[2-[4-(2-methylphenyl)-1-piperazinyl]ethyl]-s-triazolo[4,3-a]pyridine Hydrochloride; Glamidolo Hydrochloride; Remydrial; α1-Adrenoceptor Antagonist Dapiprazole; 1H-s-Triazolo[4,3-a]pyridine, 5,6,7,8-tetrahydro-3-[2-[4-(2-methylphenyl)-1-piperazinyl]ethyl]-, monohydrochloride
EINECS	Contact for details

Quality Control

Our Dapiprazole Hydrochloride is manufactured under strict quality systems to ensure it meets the stringent requirements for pharmaceutical applications. Each batch is subjected to comprehensive analytical testing, including identification, purity assay, and impurity profiling via advanced techniques like HPLC. A Certificate of Analysis (COA) documenting compliance with agreed specifications is provided with every shipment, supporting regulatory filings and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water (KF Titration)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 1.0%; Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.