Description

Piritrexim is a potent and selective dihydrofolate reductase (DHFR) inhibitor with significant research and development interest. This compound is primarily valued for its targeted mechanism of action, which makes it a key intermediate and reference standard in pharmaceutical research. It is essential for scientists and manufacturers in the pharmaceutical and biotechnology sectors, particularly those focused on developing novel antimetabolite therapies and conducting biochemical pathway studies.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of advanced drug candidates targeting folate metabolism.
• Biochemical Research: Used as a reference standard and tool compound in enzymatic studies of dihydrofolate reductase (DHFR) activity and inhibition.
• Antifolate Agent Development: A key molecule for research into new therapeutic agents for conditions where folate metabolism is a target.
• Academic & Institutional Research: Employed in university and laboratory settings for pharmacological and mechanistic studies.
• Quality Control & Analytical Standards: Utilized as a high-purity standard in HPLC, LC-MS, and other analytical methods for method development and validation.

Basic Information

Product Name	Piritrexim
CAS No.	72732-56-0
Molecular Formula	C16H19N5O4
Molecular Weight	345.35 g/mol
Synonyms	Piritrexim; BW 301U; 2,4-Diamino-6-(2,5-dimethoxybenzyl)-5-methylpyrido[2,3-d]pyrimidine; PTX; NSC 351521; 5-Methyl-2,4-diamino-6-[(2,5-dimethoxyphenyl)methyl]pyrido[2,3-d]pyrimidine
EINECS	Contact for details

Quality Control

Our Piritrexim is produced under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including identification, assay, and impurity profiling via advanced techniques like HPLC and mass spectrometry. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.