Description

Suc-Gly-Pro-Leu-Gly-Pro-Amc CAS NO 72698-36-3 is a specialized fluorogenic peptide substrate designed for the sensitive detection and quantification of matrix metalloproteinase (MMP) activity, particularly collagenase. This compound matters because it provides a critical tool for researchers in biochemistry and pharmaceutical development to study enzymatic mechanisms, screen for potential inhibitors, and understand disease progression related to tissue remodeling. It is essential for professionals in academic research, drug discovery, and diagnostic assay development who require reliable, high-purity biochemical reagents.

Application

• Enzymatic Activity Assays: Primary substrate for the fluorometric determination of collagenase (MMP-1, MMP-8, MMP-13) and gelatinase activity.
• Drug Discovery & Screening: Used in high-throughput screening (HTS) platforms to identify and evaluate novel MMP inhibitors as potential therapeutic agents.
• Biochemical Research: A key reagent for studying the kinetics, specificity, and regulation of matrix metalloproteinases in vitro.
• Disease Mechanism Studies: Facilitates research into pathologies involving extracellular matrix degradation, such as cancer metastasis, arthritis, and cardiovascular diseases.
• Diagnostic Development: Employed in the development of clinical and research-grade assay kits for measuring MMP levels in biological samples.

Basic Information

Product Name	Suc-Gly-Pro-Leu-Gly-Pro-Amc
CAS No.	72698-36-3
Molecular Formula	C30H41N7O10
Molecular Weight	659.69 g/mol
Synonyms	Succinyl-Gly-Pro-Leu-Gly-Pro-7-Amino-4-methylcoumarin; Suc-Gly-Pro-Leu-Gly-Pro-AMC; MMP Substrate I (Collagenase Substrate); Fluorogenic MMP Substrate; 7-Amino-4-methylcoumarin-labeled peptide substrate; Suc-GPLGP-AMC; EC 3.4.24.- substrate
EINECS	Contact for details

Quality Control

Our Suc-Gly-Pro-Leu-Gly-Pro-Amc is manufactured under strict quality protocols to ensure batch-to-batch consistency and high performance in sensitive assays. Each lot undergoes rigorous analytical testing, including HPLC for purity verification and functional activity testing. Certificates of Analysis (COA) detailing purity, identity, and performance data are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95% (Area Percent)
Water Content (KF)	≤ 5.0 %
Functional Activity	Conforms to reference standard

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.