Description

Suc-Ala-Ala-Pro-Nle-Pna CAS NO 72682-72-5 is a specialized synthetic peptide substrate designed for biochemical research and pharmaceutical development. This compound is critical for studying and quantifying the activity of specific proteolytic enzymes, such as elastase and related serine proteases. It is an essential tool for researchers and quality control laboratories in the pharmaceutical, biotechnology, and diagnostic sectors who require precise and reliable enzyme activity assays.

Application

• Enzyme Activity Assays: Primary substrate for the spectrophotometric or fluorometric determination of human leukocyte elastase (HLE) and other serine protease activities.
• Pharmaceutical R&D: Used in high-throughput screening (HTS) to identify and characterize novel elastase inhibitors for therapeutic applications in conditions like chronic obstructive pulmonary disease (COPD) and cystic fibrosis.
• Biochemical Research: A key reagent for kinetic studies, enzyme mechanism elucidation, and substrate specificity profiling in academic and industrial laboratories.
• Diagnostic Development: Employed in the development of clinical diagnostic kits to measure elastase levels in biological samples.
• Quality Control: Serves as a reference standard for the quality control of enzyme preparations and inhibitor compounds in manufacturing processes.

Basic Information

Product Name	Suc-Ala-Ala-Pro-Nle-Pna
CAS No.	72682-72-5
Molecular Formula	C27H39N7O8
Molecular Weight	589.65 g/mol
Synonyms	Suc-AAPF-pNA; N-Succinyl-Ala-Ala-Pro-Nle-p-Nitroanilide; N-Succinyl-L-Alanyl-L-Alanyl-L-Prolyl-L-Norleucyl-p-Nitroanilide; Suc-AAPF-pNA (Nle variant); Elastase Substrate IV; Suc-(Ala)2-Pro-Nle-pNA; Suc-AAPN-pNA; N-Succinyl-Ala-Ala-Pro-Norleu-pNA
EINECS	Contact for details

Quality Control

Our Suc-Ala-Ala-Pro-Nle-Pna is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and performance in standard assay conditions. We adhere to relevant industry guidelines for peptide synthesis and can provide material tailored to specific research or GMP-grade requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, DMF; slightly soluble in water
Performance (Enzyme Assay)	Conforms to reference standard activity

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.