Description

Pyr-Pro-Arg-Pna CAS NO 72194-57-1 is a high-purity synthetic peptide substrate, specifically designed for biochemical research and diagnostic applications. This compound is a critical reagent for the study and quantification of serine protease activity, particularly thrombin and related enzymes. It is essential for researchers and manufacturers in the fields of pharmaceutical development, clinical diagnostics, and life science research who require reliable and sensitive tools for enzyme kinetics and assay development.

Application

• Biochemical Research: As a chromogenic substrate for kinetic studies and characterization of serine proteases like thrombin, trypsin, and factor Xa.
• Diagnostic Assay Development: A key component in the formulation of in-vitro diagnostic (IVD) kits for measuring coagulation factors and other protease activities in clinical samples.
• Pharmaceutical Screening: Used in high-throughput screening (HTS) platforms to identify and evaluate potential inhibitors of thrombin and related proteases for drug discovery.
• Quality Control in Biologics: Employed in potency testing and quality assurance of therapeutic proteins and enzymes within biomanufacturing processes.
• Academic Research: Fundamental tool for university and institutional labs studying hemostasis, thrombosis, and protease signaling pathways.

Basic Information

Item	Detail
Product Name	Pyr-Pro-Arg-Pna
CAS No.	72194-57-1
Molecular Formula	C24H34N8O6
Molecular Weight	530.58 g/mol
Synonyms	Pyroglutamyl-Prolyl-Arginyl-p-Nitroanilide; H-pGlu-Pro-Arg-pNA; Chromogenic Substrate S-2366 (component); Thrombin Substrate I; Tosyl-Gly-Pro-Arg-pNA (related); Bz-Phe-Val-Arg-pNA (analogous); pGlu-Pro-Arg-pNA; Chromozym TH
EINECS	Contact for details

Quality Control

Our Pyr-Pro-Arg-Pna is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification, mass spectrometry (MS) for identity confirmation, and spectrophotometric analysis for functional performance. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Our commitment to consistency and reliability supports your critical research and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, desiccate at low temperature. Allow the product to equilibrate to room temperature in a dry atmosphere before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Absorbance Spectrum	Conforms to characteristic profile
Solubility	Soluble in water, DMSO
Functional Activity	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.